Adipokines and coronary vasomotor dysfunction

Jarrod D. Knudson, Gregory M. Dick, Johnathan Tune

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Research in the last 10-15 years has shown that fat cells (adipocytes) produce and release proteins with specific biologic activities. These proteins, termed adipokines, include the hormones leptin, adiponectin, and resistin. Adipose tissue is now recognized as an active endocrine organ. With the obesity pandemic swelling in the Western world, ongoing research is aimed at determining the biologic links between obesity and cardiovascular disease. This review presents basic historical background information on the major adipokines, introduces findings from clinical studies associating adipokines with cardiovascular disease, and summarizes results from recent basic science research studies of mechanisms of adipokine-induced cardiovascular dysfunction. Particular emphasis is placed on the action of adipokines in the coronary circulation - especially effects of adipokines on endothelial function, as endothelial damage is likely a critical event initiating atherosclerotic coronary artery disease.

Original languageEnglish
Pages (from-to)727-736
Number of pages10
JournalExperimental Biology and Medicine
Volume232
Issue number6
StatePublished - Jun 2007

Fingerprint

Adipokines
Adipocytes
Cardiovascular Diseases
Obesity
Research
Resistin
Coronary Circulation
Western World
Adiponectin
Pandemics
Leptin
Swelling
Adipose Tissue
Coronary Artery Disease
Proteins
Fats
Hormones
Tissue

Keywords

  • Adipokine
  • Adiponectin
  • Coronary blood flow
  • Leptin
  • Resistin
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Adipokines and coronary vasomotor dysfunction. / Knudson, Jarrod D.; Dick, Gregory M.; Tune, Johnathan.

In: Experimental Biology and Medicine, Vol. 232, No. 6, 06.2007, p. 727-736.

Research output: Contribution to journalArticle

Knudson, JD, Dick, GM & Tune, J 2007, 'Adipokines and coronary vasomotor dysfunction', Experimental Biology and Medicine, vol. 232, no. 6, pp. 727-736.
Knudson, Jarrod D. ; Dick, Gregory M. ; Tune, Johnathan. / Adipokines and coronary vasomotor dysfunction. In: Experimental Biology and Medicine. 2007 ; Vol. 232, No. 6. pp. 727-736.
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