Adipokines and coronary vasomotor dysfunction

Jarrod D. Knudson, Gregory M. Dick, Johnathan D. Tune

Research output: Contribution to journalShort survey

28 Scopus citations

Abstract

Research in the last 10-15 years has shown that fat cells (adipocytes) produce and release proteins with specific biologic activities. These proteins, termed adipokines, include the hormones leptin, adiponectin, and resistin. Adipose tissue is now recognized as an active endocrine organ. With the obesity pandemic swelling in the Western world, ongoing research is aimed at determining the biologic links between obesity and cardiovascular disease. This review presents basic historical background information on the major adipokines, introduces findings from clinical studies associating adipokines with cardiovascular disease, and summarizes results from recent basic science research studies of mechanisms of adipokine-induced cardiovascular dysfunction. Particular emphasis is placed on the action of adipokines in the coronary circulation - especially effects of adipokines on endothelial function, as endothelial damage is likely a critical event initiating atherosclerotic coronary artery disease.

Original languageEnglish (US)
Pages (from-to)727-736
Number of pages10
JournalExperimental Biology and Medicine
Volume232
Issue number6
StatePublished - Jun 1 2007

Keywords

  • Adipokine
  • Adiponectin
  • Coronary blood flow
  • Leptin
  • Resistin
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Knudson, J. D., Dick, G. M., & Tune, J. D. (2007). Adipokines and coronary vasomotor dysfunction. Experimental Biology and Medicine, 232(6), 727-736.