Advanced cognitive training for breast cancer survivors

A randomized controlled trial

Diane Von Ah, Janet Carpenter, Andrew Saykin, Patrick Monahan, Jingwei Wu, Menggang Yu, George Rebok, Karlene Ball, Bryan Schneider, Michael Weaver, Eileen Tallman, Frederick Unverzagt

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

The purpose of this study was to evaluate the preliminary efficacy and satisfaction/acceptability of training in memory or speed of processing versus wait-list control for improving cognitive function in breast cancer survivors. 82 breast cancer survivors completed a threegroup randomized, controlled trial. Primary outcomes were objective neuropsychological tests of memory and speed of processing. Secondary outcomes were perceived cognitive functioning, symptom distress (mood disturbance, anxiety, and fatigue), quality of life, and intervention satisfaction/ acceptability. Data were collected at baseline, post-intervention, and 2-month follow-up. Using repeated-measures mixed-linear ANCOVA models, each intervention was compared to wait-list control while adjusting for age, education, and baseline measures. The effect sizes for differences in means and the reliable improvement percentage were reported. The results show that domainspecific effects were seen for both interventions: memory training improved memory performance at 2-month follow-up (p = 0.036, d = 0.59); speed of processing training improved processing speed post-intervention (p = 0.040, d = 0.55) and 2-month follow-up (p = 0.016; d = 0.67). Transfer effects to non-trained domains were seen for speed of processing training with improved memory postintervention (p = 0.007, d = 0.75) and 2-month follow-up (p = 0.004, d = 0.82). Both interventions were associated with improvements in perceived cognitive functioning, symptom distress, and quality of life. Ratings of satisfaction/ acceptability were high for both interventions. It was concluded that while both interventions appeared promising, speed of processing training resulted in immediate and durable improvements in objective measures of processing speed and verbal memory. Speed of processing training may have broader benefits in this clinical population.

Original languageEnglish
Pages (from-to)799-809
Number of pages11
JournalBreast Cancer Research and Treatment
Volume135
Issue number3
DOIs
StatePublished - Oct 2012

Fingerprint

Survivors
Randomized Controlled Trials
Breast Neoplasms
Neurobehavioral Manifestations
Quality of Life
Learning
Neuropsychological Tests
Cognition
Fatigue
Linear Models
Anxiety
Education
Population

Keywords

  • Breast cancer survivors
  • Memory
  • Quality of life
  • Speed of processing
  • Symptom distress

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Advanced cognitive training for breast cancer survivors : A randomized controlled trial. / Von Ah, Diane; Carpenter, Janet; Saykin, Andrew; Monahan, Patrick; Wu, Jingwei; Yu, Menggang; Rebok, George; Ball, Karlene; Schneider, Bryan; Weaver, Michael; Tallman, Eileen; Unverzagt, Frederick.

In: Breast Cancer Research and Treatment, Vol. 135, No. 3, 10.2012, p. 799-809.

Research output: Contribution to journalArticle

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