Advanced extragonadal germ-cell tumors. Successful treatment with combination chemotherapy

J. D. Hainsworth, Lawrence Einhorn, S. D. Williams, M. Stewart, F. A. Greco

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Thirty-two patients with primary extragonadal germ-cell tumors were treated at Vanderbilt and Indiana University Hospitals during the period from 1976 to 1981. Thirty-one patients had far-advanced disease when treatment was begun. All patients received intensive cisplatin-containing combination chemotherapy regimens. Tumors remaining after chemotherapy were surgically removed when feasible. Of the 31 evaluable patients, 18 have been continuously disease-free after therapy, 21 patients had a complete remission; the remaining 10 had partial response. Eighty-nine percent of patients with complete remission remain free of disease after median follow-up of 30 months. No relapses occurred after 12 months of complete remission. Patients with partial response had a median survival of 9 months with no long-term survivors. Response rates and survival are similar to patients with advanced-stage testicular germ-cell tumors. Extragonadal germ-cell tumors are as curable as testicular germ-cell tumors when treated with intensive cisplatin-containing combination chemotherapy regimens, and surgical resection when necessary.

Original languageEnglish (US)
Pages (from-to)7-11
Number of pages5
JournalAnnals of Internal Medicine
Volume97
Issue number1
StatePublished - 1982
Externally publishedYes

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Germ Cell and Embryonal Neoplasms
Combination Drug Therapy
Therapeutics
Cisplatin
Survivors
Survival Rate
Recurrence
Drug Therapy
Survival

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hainsworth, J. D., Einhorn, L., Williams, S. D., Stewart, M., & Greco, F. A. (1982). Advanced extragonadal germ-cell tumors. Successful treatment with combination chemotherapy. Annals of Internal Medicine, 97(1), 7-11.

Advanced extragonadal germ-cell tumors. Successful treatment with combination chemotherapy. / Hainsworth, J. D.; Einhorn, Lawrence; Williams, S. D.; Stewart, M.; Greco, F. A.

In: Annals of Internal Medicine, Vol. 97, No. 1, 1982, p. 7-11.

Research output: Contribution to journalArticle

Hainsworth, JD, Einhorn, L, Williams, SD, Stewart, M & Greco, FA 1982, 'Advanced extragonadal germ-cell tumors. Successful treatment with combination chemotherapy', Annals of Internal Medicine, vol. 97, no. 1, pp. 7-11.
Hainsworth, J. D. ; Einhorn, Lawrence ; Williams, S. D. ; Stewart, M. ; Greco, F. A. / Advanced extragonadal germ-cell tumors. Successful treatment with combination chemotherapy. In: Annals of Internal Medicine. 1982 ; Vol. 97, No. 1. pp. 7-11.
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