Advanced testicular cancer

Update for urologists

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Purpose: Testicular cancer is a model for a curable neoplasm. We review past and present accomplishments in treating testis cancer and emphasize controversial surgical issues of interest to the urologist. Materials and Methods: We reviewed early and recent chemotherapy trials of germ cell tumors, stressing random prospective phase III studies. In addition, we address specific and complicated issues that are of particular relevance for the urologist, analyzing recently published articles. Results: Cisplatin combination chemotherapy has dramatically improved the cure rate for patients with germ cell tumors. The indications for post-chemotherapy resection for residual masses are discussed. Conclusions: The major goal 25 years ago was to develop a successful chemotherapy regimen for disseminated disease, which has now been accomplished with cisplatin combination chemotherapy. Present issues include optimal treatment in patients with poor prognostic characteristics, salvage chemotherapy strategies and indications for post-chemotherapy surgical resection.

Original languageEnglish
Pages (from-to)1964-1969
Number of pages6
JournalJournal of Urology
Volume160
Issue number6 I
StatePublished - 1998

Fingerprint

Testicular Neoplasms
Drug Therapy
Germ Cell and Embryonal Neoplasms
Combination Drug Therapy
Cisplatin
Urologists
Neoplasms

Keywords

  • Cisplatin
  • Drug therapy
  • Testicular neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

Advanced testicular cancer : Update for urologists. / Einhorn, Lawrence.

In: Journal of Urology, Vol. 160, No. 6 I, 1998, p. 1964-1969.

Research output: Contribution to journalArticle

@article{ad3d6c0184db410fb76ed8f709007c6c,
title = "Advanced testicular cancer: Update for urologists",
abstract = "Purpose: Testicular cancer is a model for a curable neoplasm. We review past and present accomplishments in treating testis cancer and emphasize controversial surgical issues of interest to the urologist. Materials and Methods: We reviewed early and recent chemotherapy trials of germ cell tumors, stressing random prospective phase III studies. In addition, we address specific and complicated issues that are of particular relevance for the urologist, analyzing recently published articles. Results: Cisplatin combination chemotherapy has dramatically improved the cure rate for patients with germ cell tumors. The indications for post-chemotherapy resection for residual masses are discussed. Conclusions: The major goal 25 years ago was to develop a successful chemotherapy regimen for disseminated disease, which has now been accomplished with cisplatin combination chemotherapy. Present issues include optimal treatment in patients with poor prognostic characteristics, salvage chemotherapy strategies and indications for post-chemotherapy surgical resection.",
keywords = "Cisplatin, Drug therapy, Testicular neoplasms",
author = "Lawrence Einhorn",
year = "1998",
language = "English",
volume = "160",
pages = "1964--1969",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "6 I",

}

TY - JOUR

T1 - Advanced testicular cancer

T2 - Update for urologists

AU - Einhorn, Lawrence

PY - 1998

Y1 - 1998

N2 - Purpose: Testicular cancer is a model for a curable neoplasm. We review past and present accomplishments in treating testis cancer and emphasize controversial surgical issues of interest to the urologist. Materials and Methods: We reviewed early and recent chemotherapy trials of germ cell tumors, stressing random prospective phase III studies. In addition, we address specific and complicated issues that are of particular relevance for the urologist, analyzing recently published articles. Results: Cisplatin combination chemotherapy has dramatically improved the cure rate for patients with germ cell tumors. The indications for post-chemotherapy resection for residual masses are discussed. Conclusions: The major goal 25 years ago was to develop a successful chemotherapy regimen for disseminated disease, which has now been accomplished with cisplatin combination chemotherapy. Present issues include optimal treatment in patients with poor prognostic characteristics, salvage chemotherapy strategies and indications for post-chemotherapy surgical resection.

AB - Purpose: Testicular cancer is a model for a curable neoplasm. We review past and present accomplishments in treating testis cancer and emphasize controversial surgical issues of interest to the urologist. Materials and Methods: We reviewed early and recent chemotherapy trials of germ cell tumors, stressing random prospective phase III studies. In addition, we address specific and complicated issues that are of particular relevance for the urologist, analyzing recently published articles. Results: Cisplatin combination chemotherapy has dramatically improved the cure rate for patients with germ cell tumors. The indications for post-chemotherapy resection for residual masses are discussed. Conclusions: The major goal 25 years ago was to develop a successful chemotherapy regimen for disseminated disease, which has now been accomplished with cisplatin combination chemotherapy. Present issues include optimal treatment in patients with poor prognostic characteristics, salvage chemotherapy strategies and indications for post-chemotherapy surgical resection.

KW - Cisplatin

KW - Drug therapy

KW - Testicular neoplasms

UR - http://www.scopus.com/inward/record.url?scp=0032324809&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032324809&partnerID=8YFLogxK

M3 - Article

VL - 160

SP - 1964

EP - 1969

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 6 I

ER -