Advances in mesenchymal stem cell research in sepsis

Todd J. Wannemuehler, Mariuxi C. Manukyan, Benjamin D. Brewster, Joshua Rouch, Jeffrey A. Poynter, Yue Wang, Daniel R. Meldrum

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: Sepsis remains a source of morbidity and mortality in the postoperative patient despite appropriate resuscitative and antimicrobial approaches. Recent research has focused upon additional interventions such as exogenous cell-based therapy. Mesenchymal stem cells (MSCs) exhibit multiple beneficial properties through their capacity for homing, attenuating the inflammatory response, modulating immune cells, and promoting tissue healing. Recent animal trials have provided evidence that MSCs may be useful therapeutic adjuncts. Materials and Methods: A directed search of recent medical literature was performed utilizing PubMed to examine the pathophysiology of sepsis, mechanisms of mesenchymal stem cell interaction with host cells, sepsis animal models, and recent trials utilizing stem cells in sepsis. Results: MSCs continue to show promise in the treatment of sepsis by their intrinsic ability to home to injured tissue, secrete paracrine signals to limit systemic and local inflammation, decrease apoptosis in threatened tissues, stimulate neoangiogenesis, activate resident stem cells, beneficially modulate immune cells, and exhibit direct antimicrobial activity. These effects are associated with reduced organ dysfunction and improved survival in animal models. Conclusion: Research utilizing animal models of sepsis has provided a greater understanding of the beneficial properties of MSCs. Their capacity to home to sites of injury and use paracrine mechanisms to change the local environment to ultimately improve organ function and survival make MSCs attractive in the treatment of sepsis. Future studies are needed to further evaluate the complex interactions between MSCs and host tissues.

Original languageEnglish
Pages (from-to)113-126
Number of pages14
JournalJournal of Surgical Research
Volume173
Issue number1
DOIs
StatePublished - Mar 2012

Fingerprint

Stem Cell Research
Mesenchymal Stromal Cells
Sepsis
Animal Models
Stem Cells
Tissue Survival
Cell- and Tissue-Based Therapy
Research
PubMed
Cell Communication
Therapeutics
Apoptosis
Inflammation
Morbidity
Survival
Mortality
Wounds and Injuries

Keywords

  • animal sepsis models
  • cell-based therapy
  • mesenchymal stem cells
  • sepsis

ASJC Scopus subject areas

  • Surgery

Cite this

Wannemuehler, T. J., Manukyan, M. C., Brewster, B. D., Rouch, J., Poynter, J. A., Wang, Y., & Meldrum, D. R. (2012). Advances in mesenchymal stem cell research in sepsis. Journal of Surgical Research, 173(1), 113-126. https://doi.org/10.1016/j.jss.2011.09.053

Advances in mesenchymal stem cell research in sepsis. / Wannemuehler, Todd J.; Manukyan, Mariuxi C.; Brewster, Benjamin D.; Rouch, Joshua; Poynter, Jeffrey A.; Wang, Yue; Meldrum, Daniel R.

In: Journal of Surgical Research, Vol. 173, No. 1, 03.2012, p. 113-126.

Research output: Contribution to journalArticle

Wannemuehler, TJ, Manukyan, MC, Brewster, BD, Rouch, J, Poynter, JA, Wang, Y & Meldrum, DR 2012, 'Advances in mesenchymal stem cell research in sepsis', Journal of Surgical Research, vol. 173, no. 1, pp. 113-126. https://doi.org/10.1016/j.jss.2011.09.053
Wannemuehler TJ, Manukyan MC, Brewster BD, Rouch J, Poynter JA, Wang Y et al. Advances in mesenchymal stem cell research in sepsis. Journal of Surgical Research. 2012 Mar;173(1):113-126. https://doi.org/10.1016/j.jss.2011.09.053
Wannemuehler, Todd J. ; Manukyan, Mariuxi C. ; Brewster, Benjamin D. ; Rouch, Joshua ; Poynter, Jeffrey A. ; Wang, Yue ; Meldrum, Daniel R. / Advances in mesenchymal stem cell research in sepsis. In: Journal of Surgical Research. 2012 ; Vol. 173, No. 1. pp. 113-126.
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