Advances in oral RNAi for disease vector mosquito research and control

Rachel M. Wiltshire, Molly Duman-Scheel

Research output: Contribution to journalReview article


Mosquito vectors in the genera Anopheles, Aedes, and Culex transmit a variety of medically important pathogens. Current vector control tools are reaching the limits of their effectiveness, necessitating the introduction of innovative vector control technologies. RNAi, which facilitates functional characterization of mosquito genes in the laboratory, could one day be applied as a new method of vector control. Recent advances in the oral administration of microbial-based systems for delivery of species-specific interfering RNA pesticides to mosquitoes may facilitate translation of this technology to the field. Oral RNAi-based pesticides represent a new class of biorational pesticides that could combat increased global incidence of insecticide resistance and which could one day become critical components of integrated human disease vector mosquito control programs.

Original languageEnglish (US)
Pages (from-to)18-23
Number of pages6
JournalCurrent Opinion in Insect Science
StatePublished - Aug 2020
Externally publishedYes

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Insect Science

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