Advances in the study of the mechanisms involved in the modulation of the expression of sclerostin in human cells

J. Delgado-Calle, F. M. Pérez-Campo, J. A. Riancho

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Sclerostin plays an important role in the regulation of bone metabolism, as is shown in the dramatic changes in bone mass which occur when its activity is inhibited by means of monoclonal antibodies. However, the mechanisms which regulate its expression are still not well-understood. Various studies have shown an association between polymorphisms of the SOST gene promoter (which codes for sclerostin) and bone mineral density. Also, the degree of methylation of a CpG island near the start of the transcription is associated with marked changes in the expression of the gene. Therefore, it appears that the production of sclerostin is influenced by both genetic and epigenetic mechanisms, in addition to other hormonal and mechanical factors. A greater knowledge of these mechanisms would not only contribute to a better understanding of bone biology, but could open up new therapeutic opportunities.

Original languageEnglish (US)
Pages (from-to)103-108
Number of pages6
JournalRevista de Osteoporosis y Metabolismo Mineral
Volume6
Issue number4
DOIs
StatePublished - Jan 1 2014

Keywords

  • Epigenetic
  • Methylation
  • SOST
  • Sclerostin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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