Advances in the understanding of ocular blood flow in glaucoma

Yochai Z. Shoshani, Alon Harris, Brent Siesky

Research output: Contribution to journalArticle

Abstract

Although intraocular pressure remains the only current treatable risk factor in open-angle glaucoma, several other risk factors have been reported, including insufficient ocular blood flow and low perfusion pressure. Over the past several decades, significant progress has been made in the methodologies utilized to assess ocular blood flow as well as consensus in interpreting their results. Utilizing these devices, dozens of prospective investigations have revealed altered ocular blood flow, ocular perfusion pressure and faulty vascular regulation in patients with open-angle glaucoma. Pilot research studies have found reductions in ocular circulation to be associated with various markers of structural and functional glaucoma progression. However, these pilot studies have been limited in size, scope and execution, and only larger, multicentered prospective controlled studies are capable of providing definitive proof of the vascular role in glaucoma progression.

Original languageEnglish
Pages (from-to)189-200
Number of pages12
JournalExpert Review of Ophthalmology
Volume5
Issue number2
DOIs
StatePublished - Apr 2010

Fingerprint

Glaucoma
Blood
Open Angle Glaucoma
Blood Vessels
Perfusion
Pressure
Intraocular Pressure
Prospective Studies
Equipment and Supplies
Research

Keywords

  • Ocular blood flow
  • Open-angle glaucoma
  • Optic nerve head structure
  • Visual function

ASJC Scopus subject areas

  • Ophthalmology
  • Biomedical Engineering
  • Optometry

Cite this

Advances in the understanding of ocular blood flow in glaucoma. / Shoshani, Yochai Z.; Harris, Alon; Siesky, Brent.

In: Expert Review of Ophthalmology, Vol. 5, No. 2, 04.2010, p. 189-200.

Research output: Contribution to journalArticle

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