Advances in understanding the postreceptor mechanisms of action of GM- CSF, G-CSF, and steel factor

Susan M. Aronica, Hal E. Broxmeyer

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Intracellular signaling events occurring downstream of receptor activation for the colony-stimulating factors GM-CSF and G-CSF and Steel factor the latter a member of the tyrosine kinase receptor family of hematopoietic growth factors, are discussed. Hematopoietic signaling pathways, including the Ras/Raf-1/MAP kinase cascade and the Jak-STAT pathway are defined and links existing between separate signaling pathways are discussed. Emphasis is given to exploring the relationships that exist between activation of receptor-associated proteins and signal transduction pathways, and the regulation of gene transcription, translation, and hematopoietic cell proliferation. A model system exploring the synergistic interaction between GM-CSF and Steel factor in the regulation of hematopoietic cell proliferation is presented.

Original languageEnglish (US)
Pages (from-to)185-190
Number of pages6
JournalCurrent opinion in hematology
Volume3
Issue number3
DOIs
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Hematology

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