Advances in understanding the postreceptor mechanisms of action of GM- CSF, G-CSF, and steel factor

Susan M. Aronica, Hal Broxmeyer

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Intracellular signaling events occurring downstream of receptor activation for the colony-stimulating factors GM-CSF and G-CSF and Steel factor the latter a member of the tyrosine kinase receptor family of hematopoietic growth factors, are discussed. Hematopoietic signaling pathways, including the Ras/Raf-1/MAP kinase cascade and the Jak-STAT pathway are defined and links existing between separate signaling pathways are discussed. Emphasis is given to exploring the relationships that exist between activation of receptor-associated proteins and signal transduction pathways, and the regulation of gene transcription, translation, and hematopoietic cell proliferation. A model system exploring the synergistic interaction between GM-CSF and Steel factor in the regulation of hematopoietic cell proliferation is presented.

Original languageEnglish
Pages (from-to)185-190
Number of pages6
JournalCurrent Opinion in Hematology
Volume3
Issue number3
StatePublished - 1996

Fingerprint

Stem Cell Factor
Granulocyte Colony-Stimulating Factor
Granulocyte-Macrophage Colony-Stimulating Factor
Colony-Stimulating Factor Receptors
Proto-Oncogene Proteins c-raf
Cell Proliferation
MAP Kinase Signaling System
Receptor Protein-Tyrosine Kinases
Signal Transduction
Intercellular Signaling Peptides and Proteins
Genes
Proteins

ASJC Scopus subject areas

  • Hematology

Cite this

Advances in understanding the postreceptor mechanisms of action of GM- CSF, G-CSF, and steel factor. / Aronica, Susan M.; Broxmeyer, Hal.

In: Current Opinion in Hematology, Vol. 3, No. 3, 1996, p. 185-190.

Research output: Contribution to journalArticle

@article{9fe892b8c5f94140950e02a3ba5cdd91,
title = "Advances in understanding the postreceptor mechanisms of action of GM- CSF, G-CSF, and steel factor",
abstract = "Intracellular signaling events occurring downstream of receptor activation for the colony-stimulating factors GM-CSF and G-CSF and Steel factor the latter a member of the tyrosine kinase receptor family of hematopoietic growth factors, are discussed. Hematopoietic signaling pathways, including the Ras/Raf-1/MAP kinase cascade and the Jak-STAT pathway are defined and links existing between separate signaling pathways are discussed. Emphasis is given to exploring the relationships that exist between activation of receptor-associated proteins and signal transduction pathways, and the regulation of gene transcription, translation, and hematopoietic cell proliferation. A model system exploring the synergistic interaction between GM-CSF and Steel factor in the regulation of hematopoietic cell proliferation is presented.",
author = "Aronica, {Susan M.} and Hal Broxmeyer",
year = "1996",
language = "English",
volume = "3",
pages = "185--190",
journal = "Current Opinion in Hematology",
issn = "1065-6251",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Advances in understanding the postreceptor mechanisms of action of GM- CSF, G-CSF, and steel factor

AU - Aronica, Susan M.

AU - Broxmeyer, Hal

PY - 1996

Y1 - 1996

N2 - Intracellular signaling events occurring downstream of receptor activation for the colony-stimulating factors GM-CSF and G-CSF and Steel factor the latter a member of the tyrosine kinase receptor family of hematopoietic growth factors, are discussed. Hematopoietic signaling pathways, including the Ras/Raf-1/MAP kinase cascade and the Jak-STAT pathway are defined and links existing between separate signaling pathways are discussed. Emphasis is given to exploring the relationships that exist between activation of receptor-associated proteins and signal transduction pathways, and the regulation of gene transcription, translation, and hematopoietic cell proliferation. A model system exploring the synergistic interaction between GM-CSF and Steel factor in the regulation of hematopoietic cell proliferation is presented.

AB - Intracellular signaling events occurring downstream of receptor activation for the colony-stimulating factors GM-CSF and G-CSF and Steel factor the latter a member of the tyrosine kinase receptor family of hematopoietic growth factors, are discussed. Hematopoietic signaling pathways, including the Ras/Raf-1/MAP kinase cascade and the Jak-STAT pathway are defined and links existing between separate signaling pathways are discussed. Emphasis is given to exploring the relationships that exist between activation of receptor-associated proteins and signal transduction pathways, and the regulation of gene transcription, translation, and hematopoietic cell proliferation. A model system exploring the synergistic interaction between GM-CSF and Steel factor in the regulation of hematopoietic cell proliferation is presented.

UR - http://www.scopus.com/inward/record.url?scp=0030002120&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030002120&partnerID=8YFLogxK

M3 - Article

C2 - 9372074

AN - SCOPUS:0030002120

VL - 3

SP - 185

EP - 190

JO - Current Opinion in Hematology

JF - Current Opinion in Hematology

SN - 1065-6251

IS - 3

ER -