Renal deterioration from nonsteroidal anti-inflammatory drugs (NSAIDs) occurs in patients with prostaglandin-dependent renal function. Whelton and colleagues in this issue show that all NSAIDs are capable of producing these effects in patients at risk. Epidemiologic studies have not supported a conclusion that any problem exists. Many of these studies, however, either lacked sensitivity or excluded patients with risk factors. Results from both interventional and better epidemiologic studies are needed to make decisions about the status of NSAIDs.
ASJC Scopus subject areas
- Internal Medicine