Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q

S. D. Detera-Wadleigh, J. A. Badner, L. R. Goldin, W. H. Berrettini, A. R. Sanders, D. Y. Rollins, G. Turner, T. Moses, H. Haerian, D. Muniec, J. I. Nurnberger, E. S. Gershon

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Abstract

In 22 multiplex pedigrees screened for linkage to bipolar disorder, by use of 18 markers on chromosome 21q, single-locus affected-sib-pair (ASP) analysis detected a high proportion (57%-62%) of alleles shared identical by descent (IBD), with P values of .049-.0008 on nine marker loci. Multilocus ASP analyses revealed locus trios in the distal region between D21S270 and D21S171, with excess allele sharing (nominal P values <.01) under two affection-status models, ASM I (bipolars and schizoaffectives) and ASM II (ASM I plus recurrent unipolars). In addition, under ASM I, the proximal interval spanned by D21S1436 and D21S65 showed locus trios with excess allele sharing (nominal P values of .03-.0003). These findings support prior evidence that a susceptibility locus for bipolar disorder is on 21q.

Original languageEnglish (US)
Pages (from-to)1279-1285
Number of pages7
JournalAmerican Journal of Human Genetics
Volume58
Issue number6
StatePublished - May 29 1996
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Detera-Wadleigh, S. D., Badner, J. A., Goldin, L. R., Berrettini, W. H., Sanders, A. R., Rollins, D. Y., Turner, G., Moses, T., Haerian, H., Muniec, D., Nurnberger, J. I., & Gershon, E. S. (1996). Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q. American Journal of Human Genetics, 58(6), 1279-1285.