Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q

S. D. Detera-Wadleigh, J. A. Badner, L. R. Goldin, W. H. Berrettini, A. R. Sanders, D. Y. Rollins, G. Turner, T. Moses, H. Haerian, D. Muniec, John Nurnberger, E. S. Gershon

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

In 22 multiplex pedigrees screened for linkage to bipolar disorder, by use of 18 markers on chromosome 21q, single-locus affected-sib-pair (ASP) analysis detected a high proportion (57%-62%) of alleles shared identical by descent (IBD), with P values of .049-.0008 on nine marker loci. Multilocus ASP analyses revealed locus trios in the distal region between D21S270 and D21S171, with excess allele sharing (nominal P values

Original languageEnglish (US)
Pages (from-to)1279-1285
Number of pages7
JournalAmerican Journal of Human Genetics
Volume58
Issue number6
StatePublished - 1996
Externally publishedYes

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Bipolar Disorder
Alleles
Pedigree
Genetic Markers

ASJC Scopus subject areas

  • Genetics

Cite this

Detera-Wadleigh, S. D., Badner, J. A., Goldin, L. R., Berrettini, W. H., Sanders, A. R., Rollins, D. Y., ... Gershon, E. S. (1996). Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q. American Journal of Human Genetics, 58(6), 1279-1285.

Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q. / Detera-Wadleigh, S. D.; Badner, J. A.; Goldin, L. R.; Berrettini, W. H.; Sanders, A. R.; Rollins, D. Y.; Turner, G.; Moses, T.; Haerian, H.; Muniec, D.; Nurnberger, John; Gershon, E. S.

In: American Journal of Human Genetics, Vol. 58, No. 6, 1996, p. 1279-1285.

Research output: Contribution to journalArticle

Detera-Wadleigh, SD, Badner, JA, Goldin, LR, Berrettini, WH, Sanders, AR, Rollins, DY, Turner, G, Moses, T, Haerian, H, Muniec, D, Nurnberger, J & Gershon, ES 1996, 'Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q', American Journal of Human Genetics, vol. 58, no. 6, pp. 1279-1285.
Detera-Wadleigh SD, Badner JA, Goldin LR, Berrettini WH, Sanders AR, Rollins DY et al. Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q. American Journal of Human Genetics. 1996;58(6):1279-1285.
Detera-Wadleigh, S. D. ; Badner, J. A. ; Goldin, L. R. ; Berrettini, W. H. ; Sanders, A. R. ; Rollins, D. Y. ; Turner, G. ; Moses, T. ; Haerian, H. ; Muniec, D. ; Nurnberger, John ; Gershon, E. S. / Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q. In: American Journal of Human Genetics. 1996 ; Vol. 58, No. 6. pp. 1279-1285.
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