African American women, metabolic syndrome, and National Cholesterol Education Program criteria

A pilot study

Susan J. Appel, Natalie A. Floyd, Joyce Newman Giger, Michael T. Weaver, Huabin Luo, Tiffany Hannah, Fernando Ovalle

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The association between elevated levels of triglycerides and insulin may be weaker in African American women (AAW) than in women of other groups, leading to underdiagnosis of the metabolic syndrome (MetS) in AAW when using the National Cholesterol Education Program (NCEP) criteria, as those criteria do not include a marker of insulin resistance, using elevated triglycerides to provide an indirect indication of insulin resistance. Objectives: To determine the degree of agreement between two definitions for the MetS, that described by the NCEP and the NCEP criteria with the addition of a marker of insulin resistance in a sample of AAW. Method: This nonexperimental pilot study took place in the General Clinical Research Center of a major medical center. Thirty-three AAW 19-45 years of age were screened using the NCEP criteria for MetS, additional markers of insulin resistance, and a 2-hour Oral Glucose Tolerance Test. Findings: Six (18%) women were classified as having the MetS using the NCEP criteria. When one of three markers for insulin resistance (hyperinsulinemia, acanthosis nigricans, or Homeostatic Model Assessment Insulin Resistance) was added to the criteria, 15 (45.5%) to 19 (59.5%) of the women were then identified as having MetS. Discussion: As identified in the literature, the prevalence of cardiovascular disease risk in AAW may be underestimated based on the sole use of the NCEP criteria. Further, because there is some evidence that insulin resistance develops before many other indicators, the addition of a marker of insulin resistance may assist in earlier identification of AAW at high risk for cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)339-346
Number of pages8
JournalNursing Research
Volume54
Issue number5
DOIs
StatePublished - Sep 2005
Externally publishedYes

Fingerprint

African Americans
Insulin Resistance
Cholesterol
Education
Triglycerides
Cardiovascular Diseases
Acanthosis Nigricans
Hyperinsulinism
Glucose Tolerance Test
Insulin
Research

Keywords

  • African American women
  • CRP
  • Insulin resistance
  • PAI-1

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Appel, S. J., Floyd, N. A., Giger, J. N., Weaver, M. T., Luo, H., Hannah, T., & Ovalle, F. (2005). African American women, metabolic syndrome, and National Cholesterol Education Program criteria: A pilot study. Nursing Research, 54(5), 339-346. https://doi.org/10.1097/00006199-200509000-00008

African American women, metabolic syndrome, and National Cholesterol Education Program criteria : A pilot study. / Appel, Susan J.; Floyd, Natalie A.; Giger, Joyce Newman; Weaver, Michael T.; Luo, Huabin; Hannah, Tiffany; Ovalle, Fernando.

In: Nursing Research, Vol. 54, No. 5, 09.2005, p. 339-346.

Research output: Contribution to journalArticle

Appel, SJ, Floyd, NA, Giger, JN, Weaver, MT, Luo, H, Hannah, T & Ovalle, F 2005, 'African American women, metabolic syndrome, and National Cholesterol Education Program criteria: A pilot study', Nursing Research, vol. 54, no. 5, pp. 339-346. https://doi.org/10.1097/00006199-200509000-00008
Appel, Susan J. ; Floyd, Natalie A. ; Giger, Joyce Newman ; Weaver, Michael T. ; Luo, Huabin ; Hannah, Tiffany ; Ovalle, Fernando. / African American women, metabolic syndrome, and National Cholesterol Education Program criteria : A pilot study. In: Nursing Research. 2005 ; Vol. 54, No. 5. pp. 339-346.
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