Age at menarche and risk of gestational diabetes mellitus: A prospective cohort study among 27,482 women

Liwei Chen, Shanshan Li, Chunyan He, Yeyi Zhu, Germaine M. Buck Louis, Edwina Yeung, Frank B. Hu, Cuilin Zhang

    Research output: Contribution to journalArticle

    15 Scopus citations

    Abstract

    Objective To examine the association between age at menarche and risk of gestational diabetes mellitus (GDM). Research Design and Methods A prospective cohort study of 42,109 eligible pregnancies from 27,482 women in the Nurses' Health Study II. Results The adjusted risk ratios for GDM across the age at menarche categories (≤11, 12, 13, and ≥14 years) were 1.34 (95% CI 1.14-1.58), 1.13 (0.97-1.31), 1.11 (0.95- 1.29), and 1.00 (referent; P for trend = 0.0005), respectively. Analysis of the mediating effect indicated that 42.1%(P = 0.0007) of the association wasmediated through prepregnancy BMI. Conclusions These findings suggested that earlier menarche was significantly associated with an increased risk of GDM. This association was largely mediated through prepregnancy excessive body adiposity.

    Original languageEnglish (US)
    Pages (from-to)469-471
    Number of pages3
    JournalDiabetes care
    Volume39
    Issue number3
    DOIs
    StatePublished - Mar 2016

    ASJC Scopus subject areas

    • Internal Medicine
    • Endocrinology, Diabetes and Metabolism
    • Advanced and Specialized Nursing

    Fingerprint Dive into the research topics of 'Age at menarche and risk of gestational diabetes mellitus: A prospective cohort study among 27,482 women'. Together they form a unique fingerprint.

  • Cite this

    Chen, L., Li, S., He, C., Zhu, Y., Buck Louis, G. M., Yeung, E., Hu, F. B., & Zhang, C. (2016). Age at menarche and risk of gestational diabetes mellitus: A prospective cohort study among 27,482 women. Diabetes care, 39(3), 469-471. https://doi.org/10.2337/dc15-2011