Age at menarche and risk of type 2 diabetes: Results from 2 large prospective cohort studies

Chunyan He, Cuilin Zhang, David J. Hunter, Susan E. Hankinson, Germaine M. Buck Louis, Mary L. Hediger, Frank B. Hu

    Research output: Contribution to journalArticle

    135 Citations (Scopus)

    Abstract

    The authors investigated the association between age at menarche and risk of type 2 diabetes mellitus (T2DM) among 101,415 women from the Nurses' Health Study (NHS) aged 34-59 years (1980-2006) and 100,547 women from Nurses' Health Study II (NHS II) aged 26-46 years (1991-2005). During 2,430,274 and 1,373,875 person-years of follow-up, respectively, 7,963 and 2,739 incident cases of T2DM were documented. Young age at menarche was associated with increased risk of T2DM after adjustment for potential confounders, including body figure at age 10 years and body mass index (BMI; weight (kg)/height (m)2) at age 18 years. Relative risks of T2DM across age-at-menarche categories (≤11, 12, 13, 14, and ≥15 years) were 1.18 (95% confidence interval (CI): 1.10, 1.27), 1.09 (95% CI: 1.02, 1.17), 1.00 (referent), 0.92 (95% CI: 0.83, 1.01), and 0.95 (95% CI: 0.84, 1.06), respectively, in the NHS (P for trend < 0.0001) and 1.40 (95% CI: 1.24, 1.57), 1.13 (95% CI: 1.00, 1.27), 1.00 (referent), 0.98 (95% CI: 0.82, 1.18), and 0.96 (95% CI: 0.78, 1.19), respectively, in NHS II (P for trend < 0.0001). Associations were substantially attenuated after additional control for updated time-varying BMI. These data suggest that early menarche is associated with increased risk of T2DM in adulthood. The association may be largely mediated through excessive adult adiposity. The association was stronger among younger women, supporting a role for sex hormones in younger onset of T2DM, in addition to BMI.

    Original languageEnglish
    Pages (from-to)334-344
    Number of pages11
    JournalAmerican Journal of Epidemiology
    Volume171
    Issue number3
    DOIs
    StatePublished - Feb 2010

    Fingerprint

    Menarche
    Type 2 Diabetes Mellitus
    Cohort Studies
    Prospective Studies
    Confidence Intervals
    Nurses
    Women's Health
    Adiposity
    Health
    Gonadal Steroid Hormones
    Body Mass Index
    Weights and Measures

    Keywords

    • Adiposity
    • Body mass index
    • Diabetes mellitus, type 2
    • Menarche
    • Risk factors
    • Weight gain

    ASJC Scopus subject areas

    • Epidemiology

    Cite this

    He, C., Zhang, C., Hunter, D. J., Hankinson, S. E., Buck Louis, G. M., Hediger, M. L., & Hu, F. B. (2010). Age at menarche and risk of type 2 diabetes: Results from 2 large prospective cohort studies. American Journal of Epidemiology, 171(3), 334-344. https://doi.org/10.1093/aje/kwp372

    Age at menarche and risk of type 2 diabetes : Results from 2 large prospective cohort studies. / He, Chunyan; Zhang, Cuilin; Hunter, David J.; Hankinson, Susan E.; Buck Louis, Germaine M.; Hediger, Mary L.; Hu, Frank B.

    In: American Journal of Epidemiology, Vol. 171, No. 3, 02.2010, p. 334-344.

    Research output: Contribution to journalArticle

    He, C, Zhang, C, Hunter, DJ, Hankinson, SE, Buck Louis, GM, Hediger, ML & Hu, FB 2010, 'Age at menarche and risk of type 2 diabetes: Results from 2 large prospective cohort studies', American Journal of Epidemiology, vol. 171, no. 3, pp. 334-344. https://doi.org/10.1093/aje/kwp372
    He, Chunyan ; Zhang, Cuilin ; Hunter, David J. ; Hankinson, Susan E. ; Buck Louis, Germaine M. ; Hediger, Mary L. ; Hu, Frank B. / Age at menarche and risk of type 2 diabetes : Results from 2 large prospective cohort studies. In: American Journal of Epidemiology. 2010 ; Vol. 171, No. 3. pp. 334-344.
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