Age, body mass, usage of exogenous estrogen, and lifestyle factors in relation to circulating sex hormone-binding globulin concentrations in postmenopausal women

Atsushi Goto, Brian H. Chen, Yiqing Song, Jane Cauley, Steven R. Cummings, Ghada N. Farhat, Marc Gunter, Linda Van Horn, Barbara V. Howard, Rebecca Jackson, Jennifer Lee, Kathryn M. Rexrode, Simin Liu

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

BACKGROUND: Circulating concentrations of sex hormone- binding globulin (SHBG) have been associated with cardiovascular diseases, type 2 diabetes, metabolic syndrome, and hormone-dependent cancers; however, correlates of SHBG concentrations are not well understood. METHODS: We comprehensively investigated correlates of SHBG concentrations among 13 547 women who participated in the Women's Health Initiative and who had SHBG measurements. We estimated study- and ethnicity-specific associations of age, reproductive history, usage of exogenous estrogen, body mass index (BMI), and lifestyle factors such as physical activity, smoking, alcohol consumption, coffee intake, and dietary factors with SHBG concentrations. These estimates were pooled using random-effects models. We also examined potential nonlinear associations using spline analyses. RESULTS: There was no significant ethnic difference in the age-adjusted mean concentrations of SHBG. Age, exogenous estrogen use, physical activity, and regular coffee intake were positively associated with SHBG concentrations, whereas BMI was inversely associated with SHBG concentrations after adjustment for potential confounding factors. Similar patterns were observed among both ever users and never users of exogenous estrogen. The spline analysis indicated nonlinear relations of regular intake of coffee, age, and BMI with SHBG concentrations. Two or more cups/day of regular coffee consumption and age of 60 years or older were associated with higher SHBG concentrations; the inverse BMI-SHBG relation was especially strong among women whose BMI was below 30. CONCLUSIONS: In this large sample of postmenopausal women, age, exogenous estrogen use, physical activity, regular coffee intake, and BMI were significant correlates of SHBG concentrations, presenting potential targets for interventions.

Original languageEnglish (US)
Pages (from-to)174-185
Number of pages12
JournalClinical Chemistry
Volume60
Issue number1
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Sex Hormone-Binding Globulin
Life Style
Estrogens
Coffee
Body Mass Index
Exercise
Splines
Reproductive History
Nonlinear analysis
Women's Health
Medical problems
Alcohol Drinking
Type 2 Diabetes Mellitus
Cardiovascular Diseases
Smoking

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Age, body mass, usage of exogenous estrogen, and lifestyle factors in relation to circulating sex hormone-binding globulin concentrations in postmenopausal women. / Goto, Atsushi; Chen, Brian H.; Song, Yiqing; Cauley, Jane; Cummings, Steven R.; Farhat, Ghada N.; Gunter, Marc; Horn, Linda Van; Howard, Barbara V.; Jackson, Rebecca; Lee, Jennifer; Rexrode, Kathryn M.; Liu, Simin.

In: Clinical Chemistry, Vol. 60, No. 1, 01.01.2014, p. 174-185.

Research output: Contribution to journalArticle

Goto, A, Chen, BH, Song, Y, Cauley, J, Cummings, SR, Farhat, GN, Gunter, M, Horn, LV, Howard, BV, Jackson, R, Lee, J, Rexrode, KM & Liu, S 2014, 'Age, body mass, usage of exogenous estrogen, and lifestyle factors in relation to circulating sex hormone-binding globulin concentrations in postmenopausal women', Clinical Chemistry, vol. 60, no. 1, pp. 174-185. https://doi.org/10.1373/clinchem.2013.207217
Goto, Atsushi ; Chen, Brian H. ; Song, Yiqing ; Cauley, Jane ; Cummings, Steven R. ; Farhat, Ghada N. ; Gunter, Marc ; Horn, Linda Van ; Howard, Barbara V. ; Jackson, Rebecca ; Lee, Jennifer ; Rexrode, Kathryn M. ; Liu, Simin. / Age, body mass, usage of exogenous estrogen, and lifestyle factors in relation to circulating sex hormone-binding globulin concentrations in postmenopausal women. In: Clinical Chemistry. 2014 ; Vol. 60, No. 1. pp. 174-185.
@article{7453d58941594251bb6344be467dc213,
title = "Age, body mass, usage of exogenous estrogen, and lifestyle factors in relation to circulating sex hormone-binding globulin concentrations in postmenopausal women",
abstract = "BACKGROUND: Circulating concentrations of sex hormone- binding globulin (SHBG) have been associated with cardiovascular diseases, type 2 diabetes, metabolic syndrome, and hormone-dependent cancers; however, correlates of SHBG concentrations are not well understood. METHODS: We comprehensively investigated correlates of SHBG concentrations among 13 547 women who participated in the Women's Health Initiative and who had SHBG measurements. We estimated study- and ethnicity-specific associations of age, reproductive history, usage of exogenous estrogen, body mass index (BMI), and lifestyle factors such as physical activity, smoking, alcohol consumption, coffee intake, and dietary factors with SHBG concentrations. These estimates were pooled using random-effects models. We also examined potential nonlinear associations using spline analyses. RESULTS: There was no significant ethnic difference in the age-adjusted mean concentrations of SHBG. Age, exogenous estrogen use, physical activity, and regular coffee intake were positively associated with SHBG concentrations, whereas BMI was inversely associated with SHBG concentrations after adjustment for potential confounding factors. Similar patterns were observed among both ever users and never users of exogenous estrogen. The spline analysis indicated nonlinear relations of regular intake of coffee, age, and BMI with SHBG concentrations. Two or more cups/day of regular coffee consumption and age of 60 years or older were associated with higher SHBG concentrations; the inverse BMI-SHBG relation was especially strong among women whose BMI was below 30. CONCLUSIONS: In this large sample of postmenopausal women, age, exogenous estrogen use, physical activity, regular coffee intake, and BMI were significant correlates of SHBG concentrations, presenting potential targets for interventions.",
author = "Atsushi Goto and Chen, {Brian H.} and Yiqing Song and Jane Cauley and Cummings, {Steven R.} and Farhat, {Ghada N.} and Marc Gunter and Horn, {Linda Van} and Howard, {Barbara V.} and Rebecca Jackson and Jennifer Lee and Rexrode, {Kathryn M.} and Simin Liu",
year = "2014",
month = "1",
day = "1",
doi = "10.1373/clinchem.2013.207217",
language = "English (US)",
volume = "60",
pages = "174--185",
journal = "Clinical Chemistry",
issn = "0009-9147",
publisher = "American Association for Clinical Chemistry Inc.",
number = "1",

}

TY - JOUR

T1 - Age, body mass, usage of exogenous estrogen, and lifestyle factors in relation to circulating sex hormone-binding globulin concentrations in postmenopausal women

AU - Goto, Atsushi

AU - Chen, Brian H.

AU - Song, Yiqing

AU - Cauley, Jane

AU - Cummings, Steven R.

AU - Farhat, Ghada N.

AU - Gunter, Marc

AU - Horn, Linda Van

AU - Howard, Barbara V.

AU - Jackson, Rebecca

AU - Lee, Jennifer

AU - Rexrode, Kathryn M.

AU - Liu, Simin

PY - 2014/1/1

Y1 - 2014/1/1

N2 - BACKGROUND: Circulating concentrations of sex hormone- binding globulin (SHBG) have been associated with cardiovascular diseases, type 2 diabetes, metabolic syndrome, and hormone-dependent cancers; however, correlates of SHBG concentrations are not well understood. METHODS: We comprehensively investigated correlates of SHBG concentrations among 13 547 women who participated in the Women's Health Initiative and who had SHBG measurements. We estimated study- and ethnicity-specific associations of age, reproductive history, usage of exogenous estrogen, body mass index (BMI), and lifestyle factors such as physical activity, smoking, alcohol consumption, coffee intake, and dietary factors with SHBG concentrations. These estimates were pooled using random-effects models. We also examined potential nonlinear associations using spline analyses. RESULTS: There was no significant ethnic difference in the age-adjusted mean concentrations of SHBG. Age, exogenous estrogen use, physical activity, and regular coffee intake were positively associated with SHBG concentrations, whereas BMI was inversely associated with SHBG concentrations after adjustment for potential confounding factors. Similar patterns were observed among both ever users and never users of exogenous estrogen. The spline analysis indicated nonlinear relations of regular intake of coffee, age, and BMI with SHBG concentrations. Two or more cups/day of regular coffee consumption and age of 60 years or older were associated with higher SHBG concentrations; the inverse BMI-SHBG relation was especially strong among women whose BMI was below 30. CONCLUSIONS: In this large sample of postmenopausal women, age, exogenous estrogen use, physical activity, regular coffee intake, and BMI were significant correlates of SHBG concentrations, presenting potential targets for interventions.

AB - BACKGROUND: Circulating concentrations of sex hormone- binding globulin (SHBG) have been associated with cardiovascular diseases, type 2 diabetes, metabolic syndrome, and hormone-dependent cancers; however, correlates of SHBG concentrations are not well understood. METHODS: We comprehensively investigated correlates of SHBG concentrations among 13 547 women who participated in the Women's Health Initiative and who had SHBG measurements. We estimated study- and ethnicity-specific associations of age, reproductive history, usage of exogenous estrogen, body mass index (BMI), and lifestyle factors such as physical activity, smoking, alcohol consumption, coffee intake, and dietary factors with SHBG concentrations. These estimates were pooled using random-effects models. We also examined potential nonlinear associations using spline analyses. RESULTS: There was no significant ethnic difference in the age-adjusted mean concentrations of SHBG. Age, exogenous estrogen use, physical activity, and regular coffee intake were positively associated with SHBG concentrations, whereas BMI was inversely associated with SHBG concentrations after adjustment for potential confounding factors. Similar patterns were observed among both ever users and never users of exogenous estrogen. The spline analysis indicated nonlinear relations of regular intake of coffee, age, and BMI with SHBG concentrations. Two or more cups/day of regular coffee consumption and age of 60 years or older were associated with higher SHBG concentrations; the inverse BMI-SHBG relation was especially strong among women whose BMI was below 30. CONCLUSIONS: In this large sample of postmenopausal women, age, exogenous estrogen use, physical activity, regular coffee intake, and BMI were significant correlates of SHBG concentrations, presenting potential targets for interventions.

UR - http://www.scopus.com/inward/record.url?scp=84891753498&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891753498&partnerID=8YFLogxK

U2 - 10.1373/clinchem.2013.207217

DO - 10.1373/clinchem.2013.207217

M3 - Article

VL - 60

SP - 174

EP - 185

JO - Clinical Chemistry

JF - Clinical Chemistry

SN - 0009-9147

IS - 1

ER -