Age of Pseudomonas aeruginosa acquisition and subsequent severity of cystic fibrosis lung disease

Jessica E. Pittman, Elizabeth H. Calloway, Michelle Kiser, John Yeatts, Stephanie Davis, Mitchell L. Drumm, Michael S. Schechter, Margaret W. Leigh, Mary Emond, Annelies Van Rie, Michael R. Knowles

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Rationale Pseudomonas aeruginosa (Pa) is associated with poor pulmonary outcomes in cystic fibrosis (CF), but the association between age of Pa infection and severity of subsequent lung disease has not been thoroughly investigated. Objective Our goal was to determine the association between age of Pa acquisition and subsequent severity of CF lung disease. Methods Case-control study using CF Foundation Registry data of 629 ΔF508 homozygotes with severe and mild lung disease (FEV1 in the lowest and highest quartile of birth cohort, respectively). Multivariate logistic regression was performed to determine the association between age of Pa acquisition and lung disease severity. Results Earlier age of Pa infection was strongly associated with increased odds of severe lung disease. For first and persistent Pa, adjusted odds ratios for severe lung disease were 6.5 (95% CI 3.1, 13.7; P <0.0001) and 11.2 (5.4, 23.1; P <0.0001), respectively, for subjects with infection before age 5 versus at ≥10 years; the association was stronger in females than males. Conclusions Earlier Pa infection, particularly before 5 years of age, is strongly associated with severe CF lung disease later in life. This study is not designed to determine causality; Pa infection may be causing lung injury, or may be a marker of ongoing inflammation and lung damage in young children with CF. Pediatr.

Original languageEnglish (US)
Pages (from-to)497-504
Number of pages8
JournalPediatric Pulmonology
Volume46
Issue number5
DOIs
StatePublished - May 2011
Externally publishedYes

Fingerprint

Cystic Fibrosis
Pseudomonas aeruginosa
Lung Diseases
Pseudomonas Infections
Homozygote
Lung Injury
Causality
Registries
Case-Control Studies
Pneumonia
Logistic Models
Odds Ratio
Parturition
Lung
Infection

Keywords

  • epidemiology
  • infection
  • lung diseases
  • obstructive
  • pediatrics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Pittman, J. E., Calloway, E. H., Kiser, M., Yeatts, J., Davis, S., Drumm, M. L., ... Knowles, M. R. (2011). Age of Pseudomonas aeruginosa acquisition and subsequent severity of cystic fibrosis lung disease. Pediatric Pulmonology, 46(5), 497-504. https://doi.org/10.1002/ppul.21397

Age of Pseudomonas aeruginosa acquisition and subsequent severity of cystic fibrosis lung disease. / Pittman, Jessica E.; Calloway, Elizabeth H.; Kiser, Michelle; Yeatts, John; Davis, Stephanie; Drumm, Mitchell L.; Schechter, Michael S.; Leigh, Margaret W.; Emond, Mary; Van Rie, Annelies; Knowles, Michael R.

In: Pediatric Pulmonology, Vol. 46, No. 5, 05.2011, p. 497-504.

Research output: Contribution to journalArticle

Pittman, JE, Calloway, EH, Kiser, M, Yeatts, J, Davis, S, Drumm, ML, Schechter, MS, Leigh, MW, Emond, M, Van Rie, A & Knowles, MR 2011, 'Age of Pseudomonas aeruginosa acquisition and subsequent severity of cystic fibrosis lung disease', Pediatric Pulmonology, vol. 46, no. 5, pp. 497-504. https://doi.org/10.1002/ppul.21397
Pittman, Jessica E. ; Calloway, Elizabeth H. ; Kiser, Michelle ; Yeatts, John ; Davis, Stephanie ; Drumm, Mitchell L. ; Schechter, Michael S. ; Leigh, Margaret W. ; Emond, Mary ; Van Rie, Annelies ; Knowles, Michael R. / Age of Pseudomonas aeruginosa acquisition and subsequent severity of cystic fibrosis lung disease. In: Pediatric Pulmonology. 2011 ; Vol. 46, No. 5. pp. 497-504.
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