Age-related changes in regional brain mitochondria from Fischer 344 rats

R. LaFrance, Nikolai Broustovetski, C. Sherburne, D. DeLong, J. M. Dubinsky

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Brain mitochondrial function has been posited to decline with aging. In order to test this hypothesis, cortical and striatal mitochondria were isolated from Fischer 344 rats at 2, 5,11, 24 and 33 months of age. Mitochondrial membrane potential remained stable through 24 months, declining slightly in mitochondria from both brain regions at 33 months. The ability of calcium to induce mitochondrial swelling and depolarization, characteristics of the permeability transition, was remarkably stable through 24 months of age and increased at advanced ages only for cortical, but not striatal, mitochondria. Striatal mitochondria were more sensitive to calcium than were cortical mitochondria throughout the first 2 years of life. A two-fold increased resistance to calcium was observed in striatal mitochondria between 5 and 11 months. Although these measurements do demonstrate changes in mitochondrial function with aging, the changes in polarization are relatively small and the increased cortical susceptibility to the permeability transition only occurred at very advanced ages. Thus mitochondrial decline with advanced age depends upon brain region.

Original languageEnglish
Pages (from-to)139-145
Number of pages7
JournalAging Cell
Volume4
Issue number3
DOIs
StatePublished - Jun 2005

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Inbred F344 Rats
Corpus Striatum
Mitochondria
Brain
Calcium
Permeability
Mitochondrial Swelling
Mitochondrial Membrane Potential

ASJC Scopus subject areas

  • Cell Biology

Cite this

Age-related changes in regional brain mitochondria from Fischer 344 rats. / LaFrance, R.; Broustovetski, Nikolai; Sherburne, C.; DeLong, D.; Dubinsky, J. M.

In: Aging Cell, Vol. 4, No. 3, 06.2005, p. 139-145.

Research output: Contribution to journalArticle

LaFrance, R. ; Broustovetski, Nikolai ; Sherburne, C. ; DeLong, D. ; Dubinsky, J. M. / Age-related changes in regional brain mitochondria from Fischer 344 rats. In: Aging Cell. 2005 ; Vol. 4, No. 3. pp. 139-145.
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