Age-related macular degeneration and the aging eye

Rita Ehrlich, Alon Harris, Nisha S. Kheradiya, Diana M. Winston, Thomas A. Ciulla, Barbara Wirostko

Research output: Contribution to journalReview article

51 Scopus citations

Abstract

Age-related macular degeneration (AMD) is an ocular disease that causes damage to the retinal macula, mostly in the elderly. Normal aging processes can lead to structural and blood flow changes that can predispose patients to AMD, although advanced age does not inevitably cause AMD. In this review, we describe changes that occur in the macular structure, such as the retinal pigment epithelium and Bruch's membrane, with advancing age and in AMD. The role of genetics in AMD and age-related changes in ocular blood flow that may play a role in the pathogenesis of AMD are also discussed. Understanding the pathophysiology of AMD development can help guide future research to further comprehend this disease and to develop better treatments to prevent its irreversible central vision loss in the elderly.

Original languageEnglish (US)
Pages (from-to)473-482
Number of pages10
JournalClinical interventions in aging
Volume3
Issue number3
StatePublished - Nov 4 2008

Keywords

  • Age-related macular degeneration
  • Aging
  • Blood flow
  • Eye
  • Macula
  • Retina
  • Vision

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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  • Cite this

    Ehrlich, R., Harris, A., Kheradiya, N. S., Winston, D. M., Ciulla, T. A., & Wirostko, B. (2008). Age-related macular degeneration and the aging eye. Clinical interventions in aging, 3(3), 473-482.