Age-related sensitivity to nicotine for inducible atrial tachycardia and atrial fibrillation

Hideki Hayashi, Chikaya Omichi, Yasushi Miyauchi, William J. Mandel, Shien-Fong Lin, Peng-Sheng Chen, Hrayr S. Karagueuzian

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Abstract

The influence of nicotine in modulating vulnerability to atrial tachycardia and fibrillation (AT/AF) remains ill defined. The isolated hearts of six young (2-3 mo) and six old (22-24 mo) male Fischer 344 rats were Langendorff perfused at 5 ml/min with oxygenated Tyrode solution at 37°C, and the whole heart was also superfused with warmed oxygenated Tyrode solution at 15 ml/min. Nicotine prolonged the interatrial conduction time and effective refractory period that were significantly (P <0.05) higher in the old than in the young rats in a concentration-dependent manner. Nicotine had a biphasic effect on burst atrial pacing-induced AT in both groups, increasing it at 10-30 ng/ml while decreasing it at 50-100 ng/ml (P <0.01). Nicotine at 10-100 ng/ml increased burst atrial pacing-induced AF in the young rats but suppressed it in the old rats (P <0.01). Optical mapping showed the presence of multiple independent wavefronts during AF and a single periodic large wavefront during AT in both groups. Nicotine, at concentrations found in the blood of smokers (30-85 ng/ml), exerts biphasic effects on inducible AT/AF in young rats and suppresses it in the old rats by causing high degrees of interatrial conduction block.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume285
Issue number5 54-5
StatePublished - Nov 2003
Externally publishedYes

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Nicotine
Tachycardia
Atrial Fibrillation
Inbred F344 Rats
Tyrode's solution

Keywords

  • Aging
  • Atrium
  • Conduction
  • Refractory period

ASJC Scopus subject areas

  • Physiology

Cite this

Age-related sensitivity to nicotine for inducible atrial tachycardia and atrial fibrillation. / Hayashi, Hideki; Omichi, Chikaya; Miyauchi, Yasushi; Mandel, William J.; Lin, Shien-Fong; Chen, Peng-Sheng; Karagueuzian, Hrayr S.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 285, No. 5 54-5, 11.2003.

Research output: Contribution to journalArticle

Hayashi, Hideki ; Omichi, Chikaya ; Miyauchi, Yasushi ; Mandel, William J. ; Lin, Shien-Fong ; Chen, Peng-Sheng ; Karagueuzian, Hrayr S. / Age-related sensitivity to nicotine for inducible atrial tachycardia and atrial fibrillation. In: American Journal of Physiology - Heart and Circulatory Physiology. 2003 ; Vol. 285, No. 5 54-5.
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