Ageing of the retinal pigment epithelium: Implications for transplantation

Mike Boulton, Malgorzata Rózanowska, Tim Wess

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

This review will discuss some of the implications for using cells from aged donors for retinal pigment epithelium (RPE) transplantation. It will consider age-related changes in the structure and function of RPE cells and the accumulation of potentially damaging photoreactive constituents. The review will focus on the role of the ocular pigments lipofuscin and melanin in respect to age-related changes in composition, photoreactivity and potential role in retinal ageing and age-related macular degeneration. The article concludes by considering the suitability of senescent RPE cells for transplantation and whether such cells can be rejuvenated.

Original languageEnglish (US)
Pages (from-to)76-84
Number of pages9
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume242
Issue number1
DOIs
StatePublished - Jan 2004
Externally publishedYes

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Retinal Pigment Epithelium
Transplantation
Lipofuscin
Melanins
Cell Transplantation
Macular Degeneration

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ageing of the retinal pigment epithelium : Implications for transplantation. / Boulton, Mike; Rózanowska, Malgorzata; Wess, Tim.

In: Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 242, No. 1, 01.2004, p. 76-84.

Research output: Contribution to journalArticle

Boulton, Mike ; Rózanowska, Malgorzata ; Wess, Tim. / Ageing of the retinal pigment epithelium : Implications for transplantation. In: Graefe's Archive for Clinical and Experimental Ophthalmology. 2004 ; Vol. 242, No. 1. pp. 76-84.
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