Aggressive course of disease in dementia

Serge Gauthier, Bruno Vellas, Martin Farlow, David Burn

Research output: Contribution to journalReview article

43 Scopus citations


The rate of disease progression in Alzheimer's disease (AD) patients is variable. A significant proportion of AD patients appear to experience an aggressive course of disease, and this has a major impact on prognosis, the patients, and their caregivers and society in general. Here we review the current literature on an aggressive course of disease in dementia and how it can be recognized in clinical practice. We also discuss the options available for treating patients with this condition.

Original languageEnglish (US)
Pages (from-to)210-217
Number of pages8
JournalAlzheimer's and Dementia
Issue number3
StatePublished - Jul 1 2006


  • Aggressive course of disease
  • Alzheimer's disease
  • Dementia
  • Rapid decline
  • Rapid progression

ASJC Scopus subject areas

  • Health Policy
  • Epidemiology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience
  • Clinical Neurology

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