Aggressive osteogenic desmoplastic melanoma: A case report

Patrick O. Emanuel, Muhammad Idrees, Anatoly Leytin, Eun Ji Kwon, Robert G. Phelps

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A case of an osteogenic desmoplastic melanoma occurring on the sole of the foot of a 60-year-old African American man is described. The tumor measured 4.8 cm in greatest dimension, invaded to a thickness of 2.2 cm and metastasized to four of ten inguinal lymph nodes. The majority of the tumor had a classic desmoplastic phenotype with malignant spindle cells set in a sclerotic and myxoid matrix and foci of lymphocyte aggregation. In other areas, there were thick trabeculae of bone rimmed by malignant epithelioid melanocytes. There was a markedly atypical lentiginous hyperplasia in the overlying epidermis. Imaging showed no continuity with the underlying calcaneus. The tumor was characterized immunohistochemically by S100 positivity. Pathologists should be aware of this diagnosis and should differentiate it from osteosarcoma.

Original languageEnglish (US)
Pages (from-to)423-426
Number of pages4
JournalJournal of Cutaneous Pathology
Volume34
Issue number5
DOIs
StatePublished - May 2007
Externally publishedYes

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Melanoma
Neoplasms
Calcaneus
Groin
Melanocytes
Osteosarcoma
Epidermis
African Americans
Hyperplasia
Foot
Lymph Nodes
Lymphocytes
Phenotype
Bone and Bones
Pathologists

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine

Cite this

Aggressive osteogenic desmoplastic melanoma : A case report. / Emanuel, Patrick O.; Idrees, Muhammad; Leytin, Anatoly; Kwon, Eun Ji; Phelps, Robert G.

In: Journal of Cutaneous Pathology, Vol. 34, No. 5, 05.2007, p. 423-426.

Research output: Contribution to journalArticle

Emanuel, Patrick O. ; Idrees, Muhammad ; Leytin, Anatoly ; Kwon, Eun Ji ; Phelps, Robert G. / Aggressive osteogenic desmoplastic melanoma : A case report. In: Journal of Cutaneous Pathology. 2007 ; Vol. 34, No. 5. pp. 423-426.
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