Aggressive surgical management of testicular carcinoma metastatic to lungs and mediastinum

I. Mandelbaum, S. D. Williams, Lawrence Einhorn

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

During the past six years, more than 200 patients were treated with chemotherapy for disseminated testicular cancer with a 70% complete remission rate. In 22 patients who were 17 to 46 years old, there was persistent thoracic disease, which was treated surgically. Six required a median sternotomy for bilateral pulmonary involvement or mediastinal metastasis. In 8 patients, chemotherapy had altered the histological appearance of the metastases from that of an undifferentiated primary tumor to a mature cystic teratoma. Five patients had nodules in the lungs, which were necrotic and fibrosed with no evidence of tumor. Nine showed embryonal cell carcinoma metastases in the lungs. All who had cystic teratoma are alive and free from disease. Three of the 5 with nodules and 1 of the 9 with metastases are currently free from disease. Aggressive surgical intervention is important in this unique group of patients in order to determine the precise pathological category of the lesions, to remove intrathoracic malignancy, and to assess the need for additonal chemotherapy. An operative mortality of zero and a low morbidity justify this approach.

Original languageEnglish
Pages (from-to)224-229
Number of pages6
JournalAnnals of Thoracic Surgery
Volume30
Issue number3
StatePublished - 1980

Fingerprint

Mediastinum
Carcinoma
Teratoma
Lung
Neoplasm Metastasis
Drug Therapy
Thoracic Diseases
Embryonal Carcinoma Stem Cells
Neoplasms
Sternotomy
Testicular Neoplasms
Morbidity
Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Aggressive surgical management of testicular carcinoma metastatic to lungs and mediastinum. / Mandelbaum, I.; Williams, S. D.; Einhorn, Lawrence.

In: Annals of Thoracic Surgery, Vol. 30, No. 3, 1980, p. 224-229.

Research output: Contribution to journalArticle

@article{cb0f818a36e34b39acafd7d20af63575,
title = "Aggressive surgical management of testicular carcinoma metastatic to lungs and mediastinum",
abstract = "During the past six years, more than 200 patients were treated with chemotherapy for disseminated testicular cancer with a 70{\%} complete remission rate. In 22 patients who were 17 to 46 years old, there was persistent thoracic disease, which was treated surgically. Six required a median sternotomy for bilateral pulmonary involvement or mediastinal metastasis. In 8 patients, chemotherapy had altered the histological appearance of the metastases from that of an undifferentiated primary tumor to a mature cystic teratoma. Five patients had nodules in the lungs, which were necrotic and fibrosed with no evidence of tumor. Nine showed embryonal cell carcinoma metastases in the lungs. All who had cystic teratoma are alive and free from disease. Three of the 5 with nodules and 1 of the 9 with metastases are currently free from disease. Aggressive surgical intervention is important in this unique group of patients in order to determine the precise pathological category of the lesions, to remove intrathoracic malignancy, and to assess the need for additonal chemotherapy. An operative mortality of zero and a low morbidity justify this approach.",
author = "I. Mandelbaum and Williams, {S. D.} and Lawrence Einhorn",
year = "1980",
language = "English",
volume = "30",
pages = "224--229",
journal = "Annals of Thoracic Surgery",
issn = "0003-4975",
publisher = "Elsevier USA",
number = "3",

}

TY - JOUR

T1 - Aggressive surgical management of testicular carcinoma metastatic to lungs and mediastinum

AU - Mandelbaum, I.

AU - Williams, S. D.

AU - Einhorn, Lawrence

PY - 1980

Y1 - 1980

N2 - During the past six years, more than 200 patients were treated with chemotherapy for disseminated testicular cancer with a 70% complete remission rate. In 22 patients who were 17 to 46 years old, there was persistent thoracic disease, which was treated surgically. Six required a median sternotomy for bilateral pulmonary involvement or mediastinal metastasis. In 8 patients, chemotherapy had altered the histological appearance of the metastases from that of an undifferentiated primary tumor to a mature cystic teratoma. Five patients had nodules in the lungs, which were necrotic and fibrosed with no evidence of tumor. Nine showed embryonal cell carcinoma metastases in the lungs. All who had cystic teratoma are alive and free from disease. Three of the 5 with nodules and 1 of the 9 with metastases are currently free from disease. Aggressive surgical intervention is important in this unique group of patients in order to determine the precise pathological category of the lesions, to remove intrathoracic malignancy, and to assess the need for additonal chemotherapy. An operative mortality of zero and a low morbidity justify this approach.

AB - During the past six years, more than 200 patients were treated with chemotherapy for disseminated testicular cancer with a 70% complete remission rate. In 22 patients who were 17 to 46 years old, there was persistent thoracic disease, which was treated surgically. Six required a median sternotomy for bilateral pulmonary involvement or mediastinal metastasis. In 8 patients, chemotherapy had altered the histological appearance of the metastases from that of an undifferentiated primary tumor to a mature cystic teratoma. Five patients had nodules in the lungs, which were necrotic and fibrosed with no evidence of tumor. Nine showed embryonal cell carcinoma metastases in the lungs. All who had cystic teratoma are alive and free from disease. Three of the 5 with nodules and 1 of the 9 with metastases are currently free from disease. Aggressive surgical intervention is important in this unique group of patients in order to determine the precise pathological category of the lesions, to remove intrathoracic malignancy, and to assess the need for additonal chemotherapy. An operative mortality of zero and a low morbidity justify this approach.

UR - http://www.scopus.com/inward/record.url?scp=0018819592&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018819592&partnerID=8YFLogxK

M3 - Article

VL - 30

SP - 224

EP - 229

JO - Annals of Thoracic Surgery

JF - Annals of Thoracic Surgery

SN - 0003-4975

IS - 3

ER -