Agreement between clinical screening procedures for neuropathy in the feet

Yi Wang, Jaclyn M. Goodrich, Robert Werner, Brenda Gillespie, Niladri Basu, Alfred Franzblau

Research output: Contribution to journalArticle

6 Scopus citations


Introduction: The correlation between monofilament testing, symptom surveys, and electrodiagnostic studies for the diagnosis of axonal polyneuropathy has not been well studied. This investigation was done to assess the agreement between these procedures in a non-random sample of volunteers. Methods: The procedures evaluated included electrodiagnostic tests of the sural nerve, monofilament testing of the great toe, a symptom survey, and a body diagram. Kappa coefficients and sensitivity and specificity, using nerve conduction as a "gold standard," were used to determine the agreement between various combinations of procedures. Results: Poor agreement (kappa values -0.12-0.44) and sensitivity (sensitivity <30%) were found for all combinations of symptoms and monofilament results in comparison with sural peak latency and amplitude. Conclusions: Overall, the results demonstrated a low discriminatory power for the screening procedures for identifying persons with impaired sural nerve function. The results highlight the need for further development and evaluation of screening methods for distal neuropathy in population-based studies.

Original languageEnglish (US)
Pages (from-to)653-658
Number of pages6
JournalMuscle and Nerve
Issue number5
StatePublished - May 2012


  • Agreement
  • Monofilament
  • Nerve conduction
  • Sural nerve, symptom

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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    Wang, Y., Goodrich, J. M., Werner, R., Gillespie, B., Basu, N., & Franzblau, A. (2012). Agreement between clinical screening procedures for neuropathy in the feet. Muscle and Nerve, 45(5), 653-658.