Background: Villous elements and dysplasia grade in small adenomas are used in many countries to guide post-polypectomy colonoscopy intervals. Aims: Measure agreement in interpretation of villous elements and dysplasia in small adenomas. Methods: Consecutive endoscopically resected adenomas <10. mm in size (203 adenomas less than 6. mm and 149 adenomas 6-9. mm in size) were reviewed by 3 expert gastrointestinal pathologists. Interpretations were compared to routine clinical pathology readings at our institution and to each other. Results: All pathologists used the same definitions for villous and tubular histology. The overall kappas for villous elements in <6. mm and 6-9. mm adenomas were 0.29 and 0.26, respectively. Interpretation of dysplasia grade had kappas of 0.02 and 0.09 for adenomas <6. mm and 6-9. mm, respectively. Two expert pathologists who used cytologic criteria had much higher fractions of high grade dysplasia compared to the third expert and the pathologists at our centre, who relied on architectural criteria. Conclusions: Villous elements and dysplasia grade in small adenomas are problematic as determinants of post-polypectomy surveillance intervals. Uniform pathologic criteria for dysplasia grade are needed.
- Villous elements
ASJC Scopus subject areas
Agreement in interpreting villous elements and dysplasia in adenomas less than one centimetre in size. / Lasisi, Femi; Mouchli, Anas; Riddell, Robert; Goldblum, John R.; Cummings, Oscar W.; Ulbright, Thomas M.; Rex, Douglas K.In: Digestive and Liver Disease, Vol. 45, No. 12, 01.12.2013, p. 1049-1055.
Research output: Contribution to journal › Article