AIDS-related CNS cryptococcosis: Radiologic-pathologic correlation

Vincent Mathews, P. L. Alo, J. D. Glass, A. J. Kumar, J. C. McArthur

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

PURPOSE: This study evaluates the effectiveness of cranial CT and MR in detecting autopsy findings of AIDS-related CNS cryptococcosis. METHODS: Final imaging studies compared with pathology were CT in eight patients (five with contrast) and MR in five patients (all with Gd-DTPA). RESULTS: Neither modality effectively identified cryptococcal meningitis. Punctate hyperintensities were seen in all patients with MR and corresponded pathologically to both perivascular spaces dilated by cryptococcal infection and cryptococcomas. Pathologically, cryptococcomas were more common than dilated perivascular spaces. MR detected more cryptococcomas than did CT, but both modalities underestimated the number of lesions seen at autopsy. Contrast enhancement of cryptococcomas and cryptococcal meningitis was uncommon. CONCLUSIONS: CNS cryptococcosis was more effectively demonstrated by MR than by CT, but both modalities underestimated the pathologic extent of the disease. Cryptococcal lesion contrast enhancement was unusual possibly because of the immunocompromised state of our patients and the unique characteristics of the organism itself.

Original languageEnglish (US)
Pages (from-to)1477-1486
Number of pages10
JournalAmerican Journal of Neuroradiology
Volume13
Issue number5
StatePublished - 1992
Externally publishedYes

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Cryptococcosis
Acquired Immunodeficiency Syndrome
Cryptococcal Meningitis
Autopsy
Gadolinium DTPA
Pathology
Infection

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Mathews, V., Alo, P. L., Glass, J. D., Kumar, A. J., & McArthur, J. C. (1992). AIDS-related CNS cryptococcosis: Radiologic-pathologic correlation. American Journal of Neuroradiology, 13(5), 1477-1486.

AIDS-related CNS cryptococcosis : Radiologic-pathologic correlation. / Mathews, Vincent; Alo, P. L.; Glass, J. D.; Kumar, A. J.; McArthur, J. C.

In: American Journal of Neuroradiology, Vol. 13, No. 5, 1992, p. 1477-1486.

Research output: Contribution to journalArticle

Mathews, V, Alo, PL, Glass, JD, Kumar, AJ & McArthur, JC 1992, 'AIDS-related CNS cryptococcosis: Radiologic-pathologic correlation', American Journal of Neuroradiology, vol. 13, no. 5, pp. 1477-1486.
Mathews, Vincent ; Alo, P. L. ; Glass, J. D. ; Kumar, A. J. ; McArthur, J. C. / AIDS-related CNS cryptococcosis : Radiologic-pathologic correlation. In: American Journal of Neuroradiology. 1992 ; Vol. 13, No. 5. pp. 1477-1486.
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