Airway IgG counteracts specific and bystander allergen-triggered pulmonary inflammation by a mechanism dependent on FcγR and IFN-γ

Sarita Sehra, Gwenda Pynaert, Kurt Tournoy, Anuschka Haegeman, Patrick Matthys, Yohichi Tagawa, Romain Pauwels, Johan Grooten

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Besides IgE, the Ab isotype that gives rise to sensitization and allergic asthma, the immune response to common inhalant allergens also includes IgG. Increased serum titers of allergen-specific IgG, induced spontaneously or by allergen vaccination, have been implicated in protection against asthma. To verify the interference of topical IgG with the allergen-triggered eosinophilic airway inflammation that underlies asthma, sensitized mice were treated by intranasal instillation of specific IgG, followed by allergen challenge. This treatment strongly reduced eosinophilic inflammation and goblet cell metaplasia, and increased Th1 reactivity and IFN-γ levels in bronchoalveolar lavage fluid. In contrast, inflammatory responses were unaffected in IFN-γ-deficient mice or when applying F(ab′)2. Although dependent on specific allergen-IgG interaction, inflammation triggered by bystander allergens was similarly repressed. Perseverance of inflammation repression, apparent after secondary allergen challenge, and increased allergen capture by alveolar macrophages further characterized the consequences of topical IgG application. These results assign a novel protective function to anti-allergen IgG namely at the local level interference with the inflammatory cascade, resulting in repression of allergic inflammation through an FcγR- and IFN-γ-dependent mechanism. Furthermore, these results provide a basis for topical immunotherapy of asthma by direct delivery of anti-allergen IgG to the airways.

Original languageEnglish (US)
Pages (from-to)2080-2089
Number of pages10
JournalJournal of Immunology
Volume171
Issue number4
StatePublished - Aug 15 2003
Externally publishedYes

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Allergens
Pneumonia
Immunoglobulin G
Inflammation
Asthma
Goblet Cells
Bronchoalveolar Lavage Fluid
Alveolar Macrophages
Metaplasia
Immunotherapy
Immunoglobulin E
Vaccination

ASJC Scopus subject areas

  • Immunology

Cite this

Sehra, S., Pynaert, G., Tournoy, K., Haegeman, A., Matthys, P., Tagawa, Y., ... Grooten, J. (2003). Airway IgG counteracts specific and bystander allergen-triggered pulmonary inflammation by a mechanism dependent on FcγR and IFN-γ. Journal of Immunology, 171(4), 2080-2089.

Airway IgG counteracts specific and bystander allergen-triggered pulmonary inflammation by a mechanism dependent on FcγR and IFN-γ. / Sehra, Sarita; Pynaert, Gwenda; Tournoy, Kurt; Haegeman, Anuschka; Matthys, Patrick; Tagawa, Yohichi; Pauwels, Romain; Grooten, Johan.

In: Journal of Immunology, Vol. 171, No. 4, 15.08.2003, p. 2080-2089.

Research output: Contribution to journalArticle

Sehra, S, Pynaert, G, Tournoy, K, Haegeman, A, Matthys, P, Tagawa, Y, Pauwels, R & Grooten, J 2003, 'Airway IgG counteracts specific and bystander allergen-triggered pulmonary inflammation by a mechanism dependent on FcγR and IFN-γ', Journal of Immunology, vol. 171, no. 4, pp. 2080-2089.
Sehra S, Pynaert G, Tournoy K, Haegeman A, Matthys P, Tagawa Y et al. Airway IgG counteracts specific and bystander allergen-triggered pulmonary inflammation by a mechanism dependent on FcγR and IFN-γ. Journal of Immunology. 2003 Aug 15;171(4):2080-2089.
Sehra, Sarita ; Pynaert, Gwenda ; Tournoy, Kurt ; Haegeman, Anuschka ; Matthys, Patrick ; Tagawa, Yohichi ; Pauwels, Romain ; Grooten, Johan. / Airway IgG counteracts specific and bystander allergen-triggered pulmonary inflammation by a mechanism dependent on FcγR and IFN-γ. In: Journal of Immunology. 2003 ; Vol. 171, No. 4. pp. 2080-2089.
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