Airway smooth muscle dynamics

A common pathway of airway obstruction in asthma

S. S. An, T. R. Bai, J. H T Bates, J. L. Black, R. H. Brown, V. Brusasco, P. Chitano, L. Deng, M. Dowell, D. H. Eidelman, B. Fabry, N. J. Fairbank, L. E. Ford, J. J. Fredberg, W. T. Gerthoffer, S. H. Gilbert, R. Gosens, Susan Gunst, A. J. Halayko, R. H. Ingram & 33 others C. G. Irvin, A. L. James, L. J. Janssen, G. G. King, D. A. Knight, A. M. Lauzon, O. J. Lakser, M. S. Ludwig, K. R. Lutchen, G. N. Maksym, J. G. Martin, T. Mauad, B. E. McParland, S. M. Mijallovich, H. W. Mitchell, R. W. Mitchell, W. Mitzner, T. M. Murphy, P. D. Paré, R. Pellegrino, M. J. Sanderson, R. R. Schellenberg, C. Y. Seow, P. S P Silveira, P. G. Smith, J. Solway, N. L. Stephens, P. J. Sterk, A. G. Stewart, D. D. Tang, Robert Tepper, T. Tran, L. Wang

Research output: Contribution to journalArticle

241 Citations (Scopus)

Abstract

Excessive airway obstruction is the cause of symptoms and abnormal lung function in asthma. As airway smooth muscle (ASM) is the effecter controlling airway calibre, it is suspected that dysfunction of ASM contributes to the pathophysiology of asthma. However, the precise role of ASM in the series of events leading to asthmatic symptoms is not clear. It is not certain whether, in asthma, there is a change in the intrinsic properties of ASM, a change in the structure and mechanical properties of the noncontractile components of the airway wall, or a change in the interdependence of the airway wall with the surrounding lung parenchyma. All these potential changes could result from acute or chronic airway inflammation and associated tissue repair and remodelling. Anti-inflammatory therapy, however, does not "cure" asthma, and airway hyperresponsiveness can persist in asthmatics, even in the absence of airway inflammation. This is perhaps because the therapy does not directly address a fundamental abnormality of asthma, that of exaggerated airway narrowing due to excessive shortening of ASM. In the present study, a central role for airway smooth muscle in the pathogenesis of airway hyperresponsiveness in asthma is explored.

Original languageEnglish
Pages (from-to)834-860
Number of pages27
JournalEuropean Respiratory Journal
Volume29
Issue number5
DOIs
StatePublished - May 2007

Fingerprint

Airway Obstruction
Smooth Muscle
Asthma
Inflammation
Lung
Anti-Inflammatory Agents
Therapeutics

Keywords

  • Airway mechanics
  • Interdependence
  • Lung function
  • Muscle adaptation
  • Muscle contraction
  • Parenchyma

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

An, S. S., Bai, T. R., Bates, J. H. T., Black, J. L., Brown, R. H., Brusasco, V., ... Wang, L. (2007). Airway smooth muscle dynamics: A common pathway of airway obstruction in asthma. European Respiratory Journal, 29(5), 834-860. https://doi.org/10.1183/09031936.00112606

Airway smooth muscle dynamics : A common pathway of airway obstruction in asthma. / An, S. S.; Bai, T. R.; Bates, J. H T; Black, J. L.; Brown, R. H.; Brusasco, V.; Chitano, P.; Deng, L.; Dowell, M.; Eidelman, D. H.; Fabry, B.; Fairbank, N. J.; Ford, L. E.; Fredberg, J. J.; Gerthoffer, W. T.; Gilbert, S. H.; Gosens, R.; Gunst, Susan; Halayko, A. J.; Ingram, R. H.; Irvin, C. G.; James, A. L.; Janssen, L. J.; King, G. G.; Knight, D. A.; Lauzon, A. M.; Lakser, O. J.; Ludwig, M. S.; Lutchen, K. R.; Maksym, G. N.; Martin, J. G.; Mauad, T.; McParland, B. E.; Mijallovich, S. M.; Mitchell, H. W.; Mitchell, R. W.; Mitzner, W.; Murphy, T. M.; Paré, P. D.; Pellegrino, R.; Sanderson, M. J.; Schellenberg, R. R.; Seow, C. Y.; Silveira, P. S P; Smith, P. G.; Solway, J.; Stephens, N. L.; Sterk, P. J.; Stewart, A. G.; Tang, D. D.; Tepper, Robert; Tran, T.; Wang, L.

In: European Respiratory Journal, Vol. 29, No. 5, 05.2007, p. 834-860.

Research output: Contribution to journalArticle

An, SS, Bai, TR, Bates, JHT, Black, JL, Brown, RH, Brusasco, V, Chitano, P, Deng, L, Dowell, M, Eidelman, DH, Fabry, B, Fairbank, NJ, Ford, LE, Fredberg, JJ, Gerthoffer, WT, Gilbert, SH, Gosens, R, Gunst, S, Halayko, AJ, Ingram, RH, Irvin, CG, James, AL, Janssen, LJ, King, GG, Knight, DA, Lauzon, AM, Lakser, OJ, Ludwig, MS, Lutchen, KR, Maksym, GN, Martin, JG, Mauad, T, McParland, BE, Mijallovich, SM, Mitchell, HW, Mitchell, RW, Mitzner, W, Murphy, TM, Paré, PD, Pellegrino, R, Sanderson, MJ, Schellenberg, RR, Seow, CY, Silveira, PSP, Smith, PG, Solway, J, Stephens, NL, Sterk, PJ, Stewart, AG, Tang, DD, Tepper, R, Tran, T & Wang, L 2007, 'Airway smooth muscle dynamics: A common pathway of airway obstruction in asthma', European Respiratory Journal, vol. 29, no. 5, pp. 834-860. https://doi.org/10.1183/09031936.00112606
An, S. S. ; Bai, T. R. ; Bates, J. H T ; Black, J. L. ; Brown, R. H. ; Brusasco, V. ; Chitano, P. ; Deng, L. ; Dowell, M. ; Eidelman, D. H. ; Fabry, B. ; Fairbank, N. J. ; Ford, L. E. ; Fredberg, J. J. ; Gerthoffer, W. T. ; Gilbert, S. H. ; Gosens, R. ; Gunst, Susan ; Halayko, A. J. ; Ingram, R. H. ; Irvin, C. G. ; James, A. L. ; Janssen, L. J. ; King, G. G. ; Knight, D. A. ; Lauzon, A. M. ; Lakser, O. J. ; Ludwig, M. S. ; Lutchen, K. R. ; Maksym, G. N. ; Martin, J. G. ; Mauad, T. ; McParland, B. E. ; Mijallovich, S. M. ; Mitchell, H. W. ; Mitchell, R. W. ; Mitzner, W. ; Murphy, T. M. ; Paré, P. D. ; Pellegrino, R. ; Sanderson, M. J. ; Schellenberg, R. R. ; Seow, C. Y. ; Silveira, P. S P ; Smith, P. G. ; Solway, J. ; Stephens, N. L. ; Sterk, P. J. ; Stewart, A. G. ; Tang, D. D. ; Tepper, Robert ; Tran, T. ; Wang, L. / Airway smooth muscle dynamics : A common pathway of airway obstruction in asthma. In: European Respiratory Journal. 2007 ; Vol. 29, No. 5. pp. 834-860.
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