Albumin protects cultured cerebellar granule neurons against zinc neurotoxicity

Suizhen Lin, Vincent S. Tagliabracci, Xianming Chen, Yansheng Du

Research output: Contribution to journalArticle

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Abstract

In this study, we have investigated the role of albumin in zinc-induced neurotoxicity of cultured rat cerebellar granule neurons. ZnCl2 induces cerebellar granule cell death in a time- and concentration-dependent manner and albumin in serum affords a significant protection against zinc-induced neurotoxicity. We further measured intracellular zinc concentrations in the presence or absence of albumin. The results showed that exogenously added ZnCl2 induced an increase in intracellular zinc concentrations in a concentration-dependent fashion in albumin-free buffer. However, in the presence of albumin, it dramatically decreased ZnCl 2-induced elevation of intracellular zinc concentrations.These results indicate that albumin protects against zinc-induced neurotoxicity by blocking extracellular zinc uptake by neurons.

Original languageEnglish (US)
Pages (from-to)1461-1465
Number of pages5
JournalNeuroReport
Volume16
Issue number13
DOIs
StatePublished - Sep 8 2005

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Keywords

  • Albumin
  • Neuronal death
  • Neuroprotection
  • Zinc

ASJC Scopus subject areas

  • Neuroscience(all)

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