Alcohol and Aldehyde Dehydrogenase Isoenzymes in North American Indians

Douglas K. Rex, William F. Bosron, John E. Smialek, Ting‐Kai ‐K Li

Research output: Contribution to journalArticle

36 Scopus citations


Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) isoenzyme phenotypes were determined in autopsy liver samples from 50 North American Indians from New Mexico. Forty-six of the 50 livers had sufficient ADH activity to allow phenotyping at the ADH2 and ADH3 loci. All 46 livers possessed the 'typical' ADH2 1-1 phenotype. The frequency of the ADH3 allele was 0.59 and is the highest thus far reported in any racial population. All 50 livers possessed the ALDH I isoenzyme which exhibits the greatest anodic mobility on starch gel electrophoresis at pH 7.6. The results show that ADH and ALDH phenotypes among American Indians living in New Mexico are very similar to those of Caucasian populations and quite different from those of Orientals.

Original languageEnglish (US)
Pages (from-to)147-152
Number of pages6
JournalAlcoholism: Clinical and Experimental Research
Issue number2
StatePublished - Mar 1985

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Alcohol and Aldehyde Dehydrogenase Isoenzymes in North American Indians'. Together they form a unique fingerprint.

  • Cite this