Alcohol and aldehyde dehydrogenase isoenzymes in North American Indians

Douglas Rex, W. F. Bosron, J. E. Smialek, T. K. Li

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) isoenzyme phenotypes were determined in autopsy liver samples from 50 North American Indians from New Mexico. Forty-six of the 50 livers had sufficient ADH activity to allow phenotyping at the ADH2 and ADH3 loci. All 46 livers possessed the 'typical' ADH2 1-1 phenotype. The frequency of the ADH3 allele was 0.59 and is the highest thus far reported in any racial population. All 50 livers possessed the ALDH I isoenzyme which exhibits the greatest anodic mobility on starch gel electrophoresis at pH 7.6. The results show that ADH and ALDH phenotypes among American Indians living in New Mexico are very similar to those of Caucasian populations and quite different from those of Orientals.

Original languageEnglish
Pages (from-to)147-152
Number of pages6
JournalAlcoholism: Clinical and Experimental Research
Volume9
Issue number2
StatePublished - 1985

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Aldehyde Dehydrogenase
North American Indians
Alcohol Dehydrogenase
Liver
Isoenzymes
Phenotype
Starch Gel Electrophoresis
Electrophoresis
Gene Frequency
Starch
Population
Autopsy
Gels

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Rex, D., Bosron, W. F., Smialek, J. E., & Li, T. K. (1985). Alcohol and aldehyde dehydrogenase isoenzymes in North American Indians. Alcoholism: Clinical and Experimental Research, 9(2), 147-152.

Alcohol and aldehyde dehydrogenase isoenzymes in North American Indians. / Rex, Douglas; Bosron, W. F.; Smialek, J. E.; Li, T. K.

In: Alcoholism: Clinical and Experimental Research, Vol. 9, No. 2, 1985, p. 147-152.

Research output: Contribution to journalArticle

Rex, D, Bosron, WF, Smialek, JE & Li, TK 1985, 'Alcohol and aldehyde dehydrogenase isoenzymes in North American Indians', Alcoholism: Clinical and Experimental Research, vol. 9, no. 2, pp. 147-152.
Rex, Douglas ; Bosron, W. F. ; Smialek, J. E. ; Li, T. K. / Alcohol and aldehyde dehydrogenase isoenzymes in North American Indians. In: Alcoholism: Clinical and Experimental Research. 1985 ; Vol. 9, No. 2. pp. 147-152.
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