Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism

Holly R. Thomasson, David Crabb, Howard Edenberg, Ting Kai Li

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

The alcohol-flush reaction occurs in Asians who inherit the mutant ALDH2*2 allele that produces an inactive aldehyde dehydrogenase enzyme. In these individuals, high blood acetaldehyde levels are believed to be the cause of the unpleasant symptoms that follow drinking. We measured the alcohol elimination rates and intensity of flushing in Chinese subjects in whom the alcohol dehydrogenase ADH2 and ALDH2 genotypes were determined. We also correlated ADH2, ADH3, and ALDH2 genotypes with drinking behavior in 100 Chinese men. We discovered that ADH2*2 and ADH3*1, alleles that encode the high activity forms of alcohol dehydrogenase, as well as the mutant ALDH2*2 allele were less frequent in alcoholics than in controls. The presence of ALDH2*2 was associated with slower alcohol metabolism and the most intense flushing. In those homozygous for ALDH2*1, the presence of two ADH2*2 alleles correlated with slightly faster alcohol metabolism and more intense flushing, although a great deal of variability in the latter was noted.

Original languageEnglish
Pages (from-to)131-136
Number of pages6
JournalBehavior Genetics
Volume23
Issue number2
DOIs
StatePublished - Mar 1993

Fingerprint

aldehyde dehydrogenase
Aldehyde Dehydrogenase
Alcohol Dehydrogenase
alcohol dehydrogenase
alcohol abuse
aldehyde
Alcoholism
alcohol
polymorphism
alcohols
Alleles
Alcohols
genetic polymorphism
alleles
allele
drinking
flushing
Genotype
Drinking Behavior
mutants

Keywords

  • alcohol dehydrogenase
  • alcohol metabolism
  • alcoholism
  • aldehyde dehydrogenase
  • Asians
  • flushing

ASJC Scopus subject areas

  • Psychology(all)
  • Behavioral Neuroscience
  • Genetics(clinical)
  • Genetics

Cite this

Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism. / Thomasson, Holly R.; Crabb, David; Edenberg, Howard; Li, Ting Kai.

In: Behavior Genetics, Vol. 23, No. 2, 03.1993, p. 131-136.

Research output: Contribution to journalArticle

Thomasson, Holly R. ; Crabb, David ; Edenberg, Howard ; Li, Ting Kai. / Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism. In: Behavior Genetics. 1993 ; Vol. 23, No. 2. pp. 131-136.
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