Alcohol and fat promote steatohepatitis: A critical role for fat-specific protein 27/CIDEC

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Abstract

Alcoholic liver disease (ALD) is a major public health problem worldwide and is the leading cause of endstage liver disease. While the ultimate control of ALD will require the prevention of alcohol abuse, better understanding of the mechanisms of alcoholinduced liver injury may lead to treatments of fatty liver, alcoholic hepatitis, and prevention or delay of occurrence of cirrhosis. The elucidation and the discovery of several new concepts in ALD pathogenesis have raised our understanding on the complex mechanisms and the potential in developing the new strategies for therapeutic benefits. In this review, we provide the most up-todate information on the basic molecular mechanisms focusing on the role of fat-specific protein 27/CIDEC in the pathogenesis of ALD.

Original languageEnglish (US)
Pages (from-to)1078-1081
Number of pages4
JournalJournal of Investigative Medicine
Volume64
Issue number6
DOIs
StatePublished - Aug 1 2016

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ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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