Alcohol and medication interactions

Ron Weathermon, David Crabb

Research output: Contribution to journalArticle

192 Citations (Scopus)

Abstract

Many medications can interact with alcohol, thereby altering the metabolism or effects of alcohol and/or the medication. Some of these interactions can occur even at moderate drinking levels and result in adverse health effects for the drinker. Two types of alcohol-medication interactions exist: (1) pharmacokinetic interactions, in which alcohol interferes with the metabolism of the medication, and (2) pharmacodynamic interactions, in which alcohol enhances the effects of the medication, particularly in the central nervous system (e.g., sedation). Pharmacokinetic interactions generally occur in the liver, where both alcohol and many medications are metabolized, frequently by the same enzymes. Numerous classes of prescription medications can interact with alcohol, including antibiotics, antidepressants, antihistamines, barbiturates, benzodiazepines, histamine H2 receptor antagonists, muscle relaxants, nonnarcotic pain medications and anti-inflammatory agents, opioids, and warfarin. In addition, many over-the-counter and herbal medications can cause negative effects when taken with alcohol.

Original languageEnglish
Pages (from-to)40-54
Number of pages15
JournalAlcohol Research and Health
Volume23
Issue number1
StatePublished - 1999

Fingerprint

Alcohols
Pharmacokinetics
Histamine H2 Antagonists
Barbiturates
Histamine Antagonists
Warfarin
Benzodiazepines
Opioid Analgesics
Antidepressive Agents
Drinking
Prescriptions
Anti-Inflammatory Agents
Central Nervous System
Anti-Bacterial Agents
Pain
Muscles
Liver
Health
Enzymes

Keywords

  • Adverse drug interaction
  • Alcohol dehydrogenases
  • Antibiotics
  • Antidepressants
  • Barbiturates
  • Benzodiazepines
  • Cytochromes
  • Drug metabolism
  • Ethanol metabolism
  • Histamine H1 receptor blockaders
  • Liver
  • Moderate AOD use
  • Prescription drug

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Alcohol and medication interactions. / Weathermon, Ron; Crabb, David.

In: Alcohol Research and Health, Vol. 23, No. 1, 1999, p. 40-54.

Research output: Contribution to journalArticle

Weathermon, R & Crabb, D 1999, 'Alcohol and medication interactions', Alcohol Research and Health, vol. 23, no. 1, pp. 40-54.
Weathermon, Ron ; Crabb, David. / Alcohol and medication interactions. In: Alcohol Research and Health. 1999 ; Vol. 23, No. 1. pp. 40-54.
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