Alcohol consumption mediates the relationship between ADH1B and DSM-IV alcohol use disorder and criteria

Bari Kilcoyne, Dvora Shmulewitz, Jacquelyn L. Meyers, Efrat Aharonovich, Eliana Greenstein, Amos Frisch, Abraham Weizman, Baruch Spivak, Howard Edenberg, Joel Gelernter, Deborah S. Hasin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

OBJECTIVE: A single nucleotide variation in the alcohol dehydrogenase 1B (ADH1B) gene, rs1229984, produces an ADH1B enzyme with faster acetaldehyde production. This protective variant is associated with lower alcohol consumption and lower risk for alcohol use disorders (AUDs). Based on the premise that faster ADH1B kinetics decreases alcohol consumption, we formally tested if the association between ADH1B variant rs1229984 and AUDs occurs through consumption. We also tested whether the association between rs1229984 and each of the 11 Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), AUD criteria occurs through consumption.

METHOD: A total of 1,130 lifetime drinkers from an Israeli household sample were assessed with a structured interview and genotyped for rs1229984 (protective allele frequency = 0.28). Logistic regression evaluated the association between rs1229984 and each phenotype (AUDs, 11 individual DSM-IV criteria). For phenotypes significantly related to rs1229984, the effect through consumption was tested with logistic regression and bootstrapping.

RESULTS: ADH1B rs1229984 was significantly associated with AUDs and six criteria, with odds ratios ranging from 1.32 to 1.96. The effect through consumption was significant for these relationships, explaining 23%-74% of the total ADH1B effect.

CONCLUSIONS: This is the first study to show that ADH1B rs1229984 is related to 6 of the 11 DSM-IV AUD criteria and that alcohol consumption explained a significant proportion of these associations and the association of ADH1B with AUDs. Better understanding of the relationship between ADH1B and the DSM-IV AUD criteria, including effects through consumption, will enhance our understanding of the etiologic model through which AUDs can occur.

Original languageEnglish
Pages (from-to)635-642
Number of pages8
JournalJournal of Studies on Alcohol and Drugs
Volume75
Issue number4
StatePublished - Jul 1 2014

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Alcohol Dehydrogenase
alcohol consumption
Diagnostic and Statistical Manual of Mental Disorders
Alcohol Drinking
alcohol
Alcohols
Logistic Models
Phenotype
Logistics
Acetaldehyde
Gene Frequency
Nucleotides
logistics
Odds Ratio
Interviews
regression
Genes
Enzymes
mental disorder

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kilcoyne, B., Shmulewitz, D., Meyers, J. L., Aharonovich, E., Greenstein, E., Frisch, A., ... Hasin, D. S. (2014). Alcohol consumption mediates the relationship between ADH1B and DSM-IV alcohol use disorder and criteria. Journal of Studies on Alcohol and Drugs, 75(4), 635-642.

Alcohol consumption mediates the relationship between ADH1B and DSM-IV alcohol use disorder and criteria. / Kilcoyne, Bari; Shmulewitz, Dvora; Meyers, Jacquelyn L.; Aharonovich, Efrat; Greenstein, Eliana; Frisch, Amos; Weizman, Abraham; Spivak, Baruch; Edenberg, Howard; Gelernter, Joel; Hasin, Deborah S.

In: Journal of Studies on Alcohol and Drugs, Vol. 75, No. 4, 01.07.2014, p. 635-642.

Research output: Contribution to journalArticle

Kilcoyne, B, Shmulewitz, D, Meyers, JL, Aharonovich, E, Greenstein, E, Frisch, A, Weizman, A, Spivak, B, Edenberg, H, Gelernter, J & Hasin, DS 2014, 'Alcohol consumption mediates the relationship between ADH1B and DSM-IV alcohol use disorder and criteria', Journal of Studies on Alcohol and Drugs, vol. 75, no. 4, pp. 635-642.
Kilcoyne B, Shmulewitz D, Meyers JL, Aharonovich E, Greenstein E, Frisch A et al. Alcohol consumption mediates the relationship between ADH1B and DSM-IV alcohol use disorder and criteria. Journal of Studies on Alcohol and Drugs. 2014 Jul 1;75(4):635-642.
Kilcoyne, Bari ; Shmulewitz, Dvora ; Meyers, Jacquelyn L. ; Aharonovich, Efrat ; Greenstein, Eliana ; Frisch, Amos ; Weizman, Abraham ; Spivak, Baruch ; Edenberg, Howard ; Gelernter, Joel ; Hasin, Deborah S. / Alcohol consumption mediates the relationship between ADH1B and DSM-IV alcohol use disorder and criteria. In: Journal of Studies on Alcohol and Drugs. 2014 ; Vol. 75, No. 4. pp. 635-642.
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abstract = "OBJECTIVE: A single nucleotide variation in the alcohol dehydrogenase 1B (ADH1B) gene, rs1229984, produces an ADH1B enzyme with faster acetaldehyde production. This protective variant is associated with lower alcohol consumption and lower risk for alcohol use disorders (AUDs). Based on the premise that faster ADH1B kinetics decreases alcohol consumption, we formally tested if the association between ADH1B variant rs1229984 and AUDs occurs through consumption. We also tested whether the association between rs1229984 and each of the 11 Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), AUD criteria occurs through consumption.METHOD: A total of 1,130 lifetime drinkers from an Israeli household sample were assessed with a structured interview and genotyped for rs1229984 (protective allele frequency = 0.28). Logistic regression evaluated the association between rs1229984 and each phenotype (AUDs, 11 individual DSM-IV criteria). For phenotypes significantly related to rs1229984, the effect through consumption was tested with logistic regression and bootstrapping.RESULTS: ADH1B rs1229984 was significantly associated with AUDs and six criteria, with odds ratios ranging from 1.32 to 1.96. The effect through consumption was significant for these relationships, explaining 23{\%}-74{\%} of the total ADH1B effect.CONCLUSIONS: This is the first study to show that ADH1B rs1229984 is related to 6 of the 11 DSM-IV AUD criteria and that alcohol consumption explained a significant proportion of these associations and the association of ADH1B with AUDs. Better understanding of the relationship between ADH1B and the DSM-IV AUD criteria, including effects through consumption, will enhance our understanding of the etiologic model through which AUDs can occur.",
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AU - Kilcoyne, Bari

AU - Shmulewitz, Dvora

AU - Meyers, Jacquelyn L.

AU - Aharonovich, Efrat

AU - Greenstein, Eliana

AU - Frisch, Amos

AU - Weizman, Abraham

AU - Spivak, Baruch

AU - Edenberg, Howard

AU - Gelernter, Joel

AU - Hasin, Deborah S.

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N2 - OBJECTIVE: A single nucleotide variation in the alcohol dehydrogenase 1B (ADH1B) gene, rs1229984, produces an ADH1B enzyme with faster acetaldehyde production. This protective variant is associated with lower alcohol consumption and lower risk for alcohol use disorders (AUDs). Based on the premise that faster ADH1B kinetics decreases alcohol consumption, we formally tested if the association between ADH1B variant rs1229984 and AUDs occurs through consumption. We also tested whether the association between rs1229984 and each of the 11 Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), AUD criteria occurs through consumption.METHOD: A total of 1,130 lifetime drinkers from an Israeli household sample were assessed with a structured interview and genotyped for rs1229984 (protective allele frequency = 0.28). Logistic regression evaluated the association between rs1229984 and each phenotype (AUDs, 11 individual DSM-IV criteria). For phenotypes significantly related to rs1229984, the effect through consumption was tested with logistic regression and bootstrapping.RESULTS: ADH1B rs1229984 was significantly associated with AUDs and six criteria, with odds ratios ranging from 1.32 to 1.96. The effect through consumption was significant for these relationships, explaining 23%-74% of the total ADH1B effect.CONCLUSIONS: This is the first study to show that ADH1B rs1229984 is related to 6 of the 11 DSM-IV AUD criteria and that alcohol consumption explained a significant proportion of these associations and the association of ADH1B with AUDs. Better understanding of the relationship between ADH1B and the DSM-IV AUD criteria, including effects through consumption, will enhance our understanding of the etiologic model through which AUDs can occur.

AB - OBJECTIVE: A single nucleotide variation in the alcohol dehydrogenase 1B (ADH1B) gene, rs1229984, produces an ADH1B enzyme with faster acetaldehyde production. This protective variant is associated with lower alcohol consumption and lower risk for alcohol use disorders (AUDs). Based on the premise that faster ADH1B kinetics decreases alcohol consumption, we formally tested if the association between ADH1B variant rs1229984 and AUDs occurs through consumption. We also tested whether the association between rs1229984 and each of the 11 Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), AUD criteria occurs through consumption.METHOD: A total of 1,130 lifetime drinkers from an Israeli household sample were assessed with a structured interview and genotyped for rs1229984 (protective allele frequency = 0.28). Logistic regression evaluated the association between rs1229984 and each phenotype (AUDs, 11 individual DSM-IV criteria). For phenotypes significantly related to rs1229984, the effect through consumption was tested with logistic regression and bootstrapping.RESULTS: ADH1B rs1229984 was significantly associated with AUDs and six criteria, with odds ratios ranging from 1.32 to 1.96. The effect through consumption was significant for these relationships, explaining 23%-74% of the total ADH1B effect.CONCLUSIONS: This is the first study to show that ADH1B rs1229984 is related to 6 of the 11 DSM-IV AUD criteria and that alcohol consumption explained a significant proportion of these associations and the association of ADH1B with AUDs. Better understanding of the relationship between ADH1B and the DSM-IV AUD criteria, including effects through consumption, will enhance our understanding of the etiologic model through which AUDs can occur.

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