Alcohol Dehydrogenases

H. J. Edenberg, W. F. Bosron

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Scopus citations

Abstract

The family of mammalian alcohol dehydrogenases (ADHs) is widely expressed, and catalyzes the oxidation and reduction of many different alcohols and aldehydes. They have overlapping distributions in different tissues, as well as overlapping substrate specificities, and play a key role in metabolism of substrates such as ethanol, retinol, and formaldehyde, among many others. Variations in the structure and expression of these enzymes are associated with differences in risk for alcoholism and for alcohol-related organ damage, including cancer. This chapter reviews the structure, regulation, and substrate specificity of these enzymes and their potential roles in pharmacogenetics and disease.

Original languageEnglish (US)
Title of host publicationBiotransformation
PublisherElsevier Inc.
Pages111-130
Number of pages20
Volume4
ISBN (Print)9780080468686
DOIs
StatePublished - Aug 12 2010

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Keywords

  • Alcohol
  • Alcoholism
  • Aldehyde
  • Cancer
  • Catalytic mechanism
  • Dehydrogenase
  • Formaldehyde
  • Gene expression
  • Metabolism
  • Polymorphisms
  • Regulation
  • Retinol
  • Structure
  • Substrate selectivity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Edenberg, H. J., & Bosron, W. F. (2010). Alcohol Dehydrogenases. In Biotransformation (Vol. 4, pp. 111-130). Elsevier Inc.. https://doi.org/10.1016/B978-0-08-046884-6.00406-1