Alcohol Dehydrogenases

H. J. Edenberg, W. F. Bosron

Research output: Chapter in Book/Report/Conference proceedingChapter

18 Scopus citations


The family of mammalian alcohol dehydrogenases (ADHs) is widely expressed, and catalyzes the oxidation and reduction of many different alcohols and aldehydes. They have overlapping distributions in different tissues, as well as overlapping substrate specificities, and play a key role in metabolism of substrates such as ethanol, retinol, and formaldehyde, among many others. Variations in the structure and expression of these enzymes are associated with differences in risk for alcoholism and for alcohol-related organ damage, including cancer. This chapter reviews the structure, regulation, and substrate specificity of these enzymes and their potential roles in pharmacogenetics and disease.

Original languageEnglish (US)
Title of host publicationBiotransformation
PublisherElsevier Inc.
Number of pages20
ISBN (Print)9780080468686
StatePublished - Aug 12 2010


  • Alcohol
  • Alcoholism
  • Aldehyde
  • Cancer
  • Catalytic mechanism
  • Dehydrogenase
  • Formaldehyde
  • Gene expression
  • Metabolism
  • Polymorphisms
  • Regulation
  • Retinol
  • Structure
  • Substrate selectivity

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Alcohol Dehydrogenases'. Together they form a unique fingerprint.

  • Cite this

    Edenberg, H. J., & Bosron, W. F. (2010). Alcohol Dehydrogenases. In Biotransformation (Vol. 4, pp. 111-130). Elsevier Inc..