Alcohol Dehydrogenases

Howard Edenberg, W. F. Bosron

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Citations (Scopus)

Abstract

The family of mammalian alcohol dehydrogenases (ADHs) is widely expressed, and catalyzes the oxidation and reduction of many different alcohols and aldehydes. They have overlapping distributions in different tissues, as well as overlapping substrate specificities, and play a key role in metabolism of substrates such as ethanol, retinol, and formaldehyde, among many others. Variations in the structure and expression of these enzymes are associated with differences in risk for alcoholism and for alcohol-related organ damage, including cancer. This chapter reviews the structure, regulation, and substrate specificity of these enzymes and their potential roles in pharmacogenetics and disease.

Original languageEnglish (US)
Title of host publicationBiotransformation
PublisherElsevier Inc.
Pages111-130
Number of pages20
Volume4
ISBN (Print)9780080468686
DOIs
StatePublished - Aug 12 2010

Fingerprint

Alcohol Dehydrogenase
Substrate Specificity
Alcohols
Pharmacogenetics
Enzymes
Vitamin A
Aldehydes
Formaldehyde
Alcoholism
Oxidation-Reduction
Ethanol
Neoplasms

Keywords

  • Alcohol
  • Alcoholism
  • Aldehyde
  • Cancer
  • Catalytic mechanism
  • Dehydrogenase
  • Formaldehyde
  • Gene expression
  • Metabolism
  • Polymorphisms
  • Regulation
  • Retinol
  • Structure
  • Substrate selectivity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Edenberg, H., & Bosron, W. F. (2010). Alcohol Dehydrogenases. In Biotransformation (Vol. 4, pp. 111-130). Elsevier Inc.. https://doi.org/10.1016/B978-0-08-046884-6.00406-1

Alcohol Dehydrogenases. / Edenberg, Howard; Bosron, W. F.

Biotransformation. Vol. 4 Elsevier Inc., 2010. p. 111-130.

Research output: Chapter in Book/Report/Conference proceedingChapter

Edenberg, H & Bosron, WF 2010, Alcohol Dehydrogenases. in Biotransformation. vol. 4, Elsevier Inc., pp. 111-130. https://doi.org/10.1016/B978-0-08-046884-6.00406-1
Edenberg H, Bosron WF. Alcohol Dehydrogenases. In Biotransformation. Vol. 4. Elsevier Inc. 2010. p. 111-130 https://doi.org/10.1016/B978-0-08-046884-6.00406-1
Edenberg, Howard ; Bosron, W. F. / Alcohol Dehydrogenases. Biotransformation. Vol. 4 Elsevier Inc., 2010. pp. 111-130
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