Alcohol Dehydrogenases

Howard Edenberg, W. F. Bosron

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The family of mammalian alcohol dehydrogenases are widely expressed and catalyze the oxidation and reduction of many different alcohols and aldehydes. They have overlapping distributions in different tissues, as well as overlapping substrate specificities, and play a key role in metabolism of substrates such as ethanol, retinol, and formaldehyde, among many others. Variations in the structure and expression of these enzymes are associated with differences in risk for alcoholism and for alcohol-related organ damage, including cancer. This article reviews the structure, regulation, and substrate specificity of these enzymes and their potential roles in pharmacogenetics and disease. Future studies of these enzymes should include more attention to how genetic variations affecting both coding and regulation influence risk for disease.

Original languageEnglish (US)
Title of host publicationBiotransformation
PublisherElsevier Inc.
Pages126-145
Number of pages20
Volume10-15
ISBN (Electronic)9780081006122
ISBN (Print)9780081006016
DOIs
StatePublished - Dec 15 2017

Fingerprint

Alcohol Dehydrogenase
Substrate Specificity
Enzymes
Alcohols
Pharmacogenetics
Vitamin A
Aldehydes
Formaldehyde
Alcoholism
Oxidation-Reduction
Ethanol
Neoplasms

Keywords

  • Alcohol
  • Alcohol dehydrogenase
  • Alcoholism
  • Aldehyde
  • Cancer
  • Catalytic mechanism
  • Formaldehyde
  • Gene expression
  • Metabolism
  • Polymorphisms
  • Regulation
  • Retinol
  • Structure
  • Substrate selectivity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Edenberg, H., & Bosron, W. F. (2017). Alcohol Dehydrogenases. In Biotransformation (Vol. 10-15, pp. 126-145). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-801238-3.01962-0

Alcohol Dehydrogenases. / Edenberg, Howard; Bosron, W. F.

Biotransformation. Vol. 10-15 Elsevier Inc., 2017. p. 126-145.

Research output: Chapter in Book/Report/Conference proceedingChapter

Edenberg, H & Bosron, WF 2017, Alcohol Dehydrogenases. in Biotransformation. vol. 10-15, Elsevier Inc., pp. 126-145. https://doi.org/10.1016/B978-0-12-801238-3.01962-0
Edenberg H, Bosron WF. Alcohol Dehydrogenases. In Biotransformation. Vol. 10-15. Elsevier Inc. 2017. p. 126-145 https://doi.org/10.1016/B978-0-12-801238-3.01962-0
Edenberg, Howard ; Bosron, W. F. / Alcohol Dehydrogenases. Biotransformation. Vol. 10-15 Elsevier Inc., 2017. pp. 126-145
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