The N/Nih heterogeneous stock rats were tested for alcohol drinking behavior. Rats that met criteria for high (> 5.0 g ethanol/kg body weight/day) and low (< 0.5 g/kg/day) alcohol consumption were chosen, and the regional brain contents of monoamine neurotransmitters were determined in these animals. The primary finding was a lower content of serotonin and 5-hydroxyindoleacetic acid in the thalamus and hypothalamus of the high alcohol preferring N/Nih rats as compared with the low perferrers. The high perferrers were also found to have a lower content of dopamine and norepinephrine in the thalamus. The findings support the density and/or metabolic functioning of regional brain serotonin systems and alcohol preference.
|Original language||English (US)|
|Number of pages||7|
|Journal||Alcohol and Drug Research|
|State||Published - Jan 1 1987|
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