Alcohol preference and regional brain monoamine contents of N/Nih heterogeneous stock rats

J. M. Murphy, W. J. McBride, L. Lumeng, T. K. Li

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The N/Nih heterogeneous stock rats were tested for alcohol drinking behavior. Rats that met criteria for high (> 5.0 g ethanol/kg body weight/day) and low (< 0.5 g/kg/day) alcohol consumption were chosen, and the regional brain contents of monoamine neurotransmitters were determined in these animals. The primary finding was a lower content of serotonin and 5-hydroxyindoleacetic acid in the thalamus and hypothalamus of the high alcohol preferring N/Nih rats as compared with the low perferrers. The high perferrers were also found to have a lower content of dopamine and norepinephrine in the thalamus. The findings support the density and/or metabolic functioning of regional brain serotonin systems and alcohol preference.

Original languageEnglish
Pages (from-to)33-39
Number of pages7
JournalAlcohol and Drug Research
Volume7
Issue number1
StatePublished - 1987

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Rats
Brain
brain
alcohol
Alcohols
Thalamus
Alcohol Drinking
Serotonin
Drinking Behavior
Hydroxyindoleacetic Acid
body weight
alcohol consumption
Hypothalamus
Neurotransmitter Agents
Dopamine
Norepinephrine
Ethanol
animal
Body Weight
Animals

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Murphy, J. M., McBride, W. J., Lumeng, L., & Li, T. K. (1987). Alcohol preference and regional brain monoamine contents of N/Nih heterogeneous stock rats. Alcohol and Drug Research, 7(1), 33-39.

Alcohol preference and regional brain monoamine contents of N/Nih heterogeneous stock rats. / Murphy, J. M.; McBride, W. J.; Lumeng, L.; Li, T. K.

In: Alcohol and Drug Research, Vol. 7, No. 1, 1987, p. 33-39.

Research output: Contribution to journalArticle

Murphy, JM, McBride, WJ, Lumeng, L & Li, TK 1987, 'Alcohol preference and regional brain monoamine contents of N/Nih heterogeneous stock rats', Alcohol and Drug Research, vol. 7, no. 1, pp. 33-39.
Murphy, J. M. ; McBride, W. J. ; Lumeng, L. ; Li, T. K. / Alcohol preference and regional brain monoamine contents of N/Nih heterogeneous stock rats. In: Alcohol and Drug Research. 1987 ; Vol. 7, No. 1. pp. 33-39.
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