Alcohol preference and regional brain monoamine contents of N/Nih heterogeneous stock rats

J. M. Murphy, W. J. McBride, L. Lumeng, T. K. Li

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Abstract

The N/Nih heterogeneous stock rats were tested for alcohol drinking behavior. Rats that met criteria for high (> 5.0 g ethanol/kg body weight/day) and low (< 0.5 g/kg/day) alcohol consumption were chosen, and the regional brain contents of monoamine neurotransmitters were determined in these animals. The primary finding was a lower content of serotonin and 5-hydroxyindoleacetic acid in the thalamus and hypothalamus of the high alcohol preferring N/Nih rats as compared with the low perferrers. The high perferrers were also found to have a lower content of dopamine and norepinephrine in the thalamus. The findings support the density and/or metabolic functioning of regional brain serotonin systems and alcohol preference.

Original languageEnglish (US)
Pages (from-to)33-39
Number of pages7
JournalAlcohol and Drug Research
Volume7
Issue number1
StatePublished - Jan 1 1987

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  • Medicine(all)

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Murphy, J. M., McBride, W. J., Lumeng, L., & Li, T. K. (1987). Alcohol preference and regional brain monoamine contents of N/Nih heterogeneous stock rats. Alcohol and Drug Research, 7(1), 33-39.