Alcohol seeking and consumption in the NVHL neurodevelopmental rat model of schizophrenia

S. A. Berg, C. L. Czachowski, R. Andrew Chambers

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Alcohol abuse in schizophrenia exceeds rates in the general population and worsens illness outcomes. Neonatal ventral hippocampal lesion (NVHL) rats model multiple schizophrenia dimensions including addiction vulnerability. This study compared NVHL vs. SHAM-controls in operant alcohol seeking and consumption. NVHLs enhanced consumption of combined ethanol/sucrose solution but neither ethanol or sucrose only solutions, consistent with increased vulnerability specific to carbohydrate-laden alcohol beverages typically consumed in early stages of human alcoholism.

Original languageEnglish (US)
Pages (from-to)346-349
Number of pages4
JournalBehavioural Brain Research
Volume218
Issue number2
DOIs
StatePublished - Apr 15 2011

Keywords

  • Addiction
  • Alcohol
  • Dual diagnosis
  • Mental illness
  • Schizophrenia
  • Substance use disorders

ASJC Scopus subject areas

  • Behavioral Neuroscience

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