Two large collaborative datasets, the Collaborative Study On the Genetics of Alcoholism (COGA) and the NIMH Genetics Initiative Bipolar Study, were analyzed to determine differences in the age of alcohol regular use and dependence between groups. There were statistically significant differences when comparing age of onset of regular drinking between parents and their offspring in all groups, with consistently earlier onset observed in the offspring. Group 1-parents (G1-p) age of onset was 20.10; Group 1-offspring (G1-o) was 16.18(t-test= 12.988 <001). There were statistically significant differences when comparing age of onset of alcohol dependence between parents and offspring, with consistently earlier onset observed in the offspring; G1-p age was 29.71, G1-o was 19.46 (t-test = 22.18 P < .001); Group 2 (G2-p) age was 29.04, G2-o was 19.11 (t-test = 3.346 P<.001). The progression from regular onset of drinking to alcohol dependence was longer in the parents when compared to their offsprings progression from use to alcohol dependence. The parental groups were similar to off spring #8217;s age of onset of regular drinking and alcoholism. Environmental factors may be most likely to account in the differences of age of onset between parental and offspring groups.
|Original language||English (US)|
|Number of pages||1|
|Journal||American Journal of Medical Genetics - Neuropsychiatric Genetics|
|State||Published - Oct 8 2001|
ASJC Scopus subject areas
- Psychiatry and Mental health
- Cellular and Molecular Neuroscience