Alcoholic-induced hepatic steatosis - Role of ceramide and protein phosphatase 2A

Rodjawan Supakul, Suthat Liangpunsakul

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

The mechanisms underlying alcohol-induced hepatic steatosis are complex, involving the disturbance of several signaling pathways. We have gained a better understanding of the role of the innate immune system in the liver and its effects on lipid metabolism and uncovered a number of circulating factors that can influence the response of the liver to ethanol. In this report, we will focus on the potential role of ceramide on AMP-activated protein kinase, as a mediator of alcohol-induced hepatic steatosis.

Original languageEnglish (US)
Pages (from-to)77-81
Number of pages5
JournalTranslational Research
Volume158
Issue number2
DOIs
StatePublished - Aug 2011
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Biochemistry, medical
  • Physiology (medical)

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