Alcoholic liver disease

Paul Y. Kwo, Lawrence Lumeng

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Ethanol is directly and indirectly hepatotoxic. The toxicity of alcohol is influenced by genetic factors (including gender differences) on the one hand and environmental variables (including nutrition, intestinal microflora, interactions with xenobiotics, and so on) on the other. In the past year, research on the pathogenesis of alcohol-induced liver injury has emphasized the importance of CYP2E1 in producing reactive oxygen species and oxidative stress, and the role of acetaldehyde and hydroxyethyl radicals in producing protein adducts. Research has further implicated a complex cascade of autocrine and paracrine pathways that involves endotoxemia, oxidative stress and activation of Kupffer cells, proliferation and transformation of hepatic stellate cells, and stimulation of sinusoidal endothelial cells.

Original languageEnglish
Pages (from-to)234-241
Number of pages8
JournalCurrent Opinion in Gastroenterology
Volume14
Issue number3
StatePublished - 1998

Fingerprint

Alcoholic Liver Diseases
Oxidative Stress
Alcohols
Cytochrome P-450 CYP2E1
Hepatic Stellate Cells
Endotoxemia
Kupffer Cells
Acetaldehyde
Xenobiotics
Research
Reactive Oxygen Species
Ethanol
Endothelial Cells
Cell Proliferation
Liver
Wounds and Injuries
Proteins
Gastrointestinal Microbiome

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Kwo, P. Y., & Lumeng, L. (1998). Alcoholic liver disease. Current Opinion in Gastroenterology, 14(3), 234-241.

Alcoholic liver disease. / Kwo, Paul Y.; Lumeng, Lawrence.

In: Current Opinion in Gastroenterology, Vol. 14, No. 3, 1998, p. 234-241.

Research output: Contribution to journalArticle

Kwo, PY & Lumeng, L 1998, 'Alcoholic liver disease', Current Opinion in Gastroenterology, vol. 14, no. 3, pp. 234-241.
Kwo PY, Lumeng L. Alcoholic liver disease. Current Opinion in Gastroenterology. 1998;14(3):234-241.
Kwo, Paul Y. ; Lumeng, Lawrence. / Alcoholic liver disease. In: Current Opinion in Gastroenterology. 1998 ; Vol. 14, No. 3. pp. 234-241.
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