Alcoholic liver disease

Lawrence Lumeng, David Crabb

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Research has substantiated the role of several mechanisms responsible for alcohol-induced hepatotoxicity. These mechanisms include: oxidative stress and lipid peroxidation; immunogenic processes initiated by formation of protein adducts of acetaldehyde, other aldehydes and l-hydroxyethyl radicals; and activation of Kupffer cells by endotoxin and subsequent cascade of events that involved cytokines, chemokines, and adhesion molecules. Increasing evidence implicates enhanced intestinal permeability caused by alcohol ingestion as the culprit that leads to endotoxemia. While oxidative stress is important, the principal source of reactive oxygen species that causes alcohol-induced liver injury is hotly debated. Potential sources may include cytochrome P450IlE1, activated Kupffer cells, and mitochondrial electron transfer chain. Apoptosis is likely an important pathway that culminates in hepatocyte cell death. Abstinence, corticosteroids, and enteral nutrition remain the cornerstones in the treatment of alcoholic hepatitis. The efficacies of medications such as S-adenosylmethionine and pentoxifylline will need further confirmation by additional randomized trials before they can be recommended as standard therapies for alcoholic hepatitis.

Original languageEnglish
Pages (from-to)211-220
Number of pages10
JournalCurrent Opinion in Gastroenterology
Volume17
Issue number3
DOIs
StatePublished - 2001

Fingerprint

Alcoholic Liver Diseases
Alcoholic Hepatitis
Kupffer Cells
Alcohols
Oxidative Stress
S-Adenosylmethionine
Pentoxifylline
Endotoxemia
Acetaldehyde
Enteral Nutrition
Cytochromes
Chemokines
Aldehydes
Endotoxins
Lipid Peroxidation
Hepatocytes
Permeability
Reactive Oxygen Species
Adrenal Cortex Hormones
Cell Death

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Alcoholic liver disease. / Lumeng, Lawrence; Crabb, David.

In: Current Opinion in Gastroenterology, Vol. 17, No. 3, 2001, p. 211-220.

Research output: Contribution to journalArticle

Lumeng, Lawrence ; Crabb, David. / Alcoholic liver disease. In: Current Opinion in Gastroenterology. 2001 ; Vol. 17, No. 3. pp. 211-220.
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