Alcoholism

Is it a model for the study of disorders of mood and consummatory behavior?

T. K. Li, L. Lumeng, W. J. McBride, J. M. Murphy

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Depression, eating disorders, and carbohydrate craving are frequently seen in alcoholics or recovering alcoholics. Accordingly, these disorders may share some mediating pathways. It is now well-established that there is a genetic predisposition to alcoholism. Through genetic means, our laboratory has developed an animal model of alcoholism. Free-fed Wistar rats were selectively bred for the traits of alcohol-preference (the P line) and non-preference (the NP line). After more than 20 generations of selection, the lines show a stable difference of more than six-fold in voluntary ethanol consumption. We have now shown that the P line satisfies all the perceived requirements of an animal model of alcoholism. One major discovered difference between the P and the NP line is the lowered content of serotonin in certain brain regions of the P rats. Interestingly, fluoxetine curbs the alcohol-seeking behavior of the P rats; variation in the carbohydrate content of the diet, however, does not modify voluntary ethanol intake. The P rats are similar in body weight to the NP rats, but are more active in a novel environment than the NP rats.

Original languageEnglish
Pages (from-to)239-249
Number of pages11
JournalAnnals of the New York Academy of Sciences
Volume499
StatePublished - 1987

Fingerprint

Consummatory Behavior
Mood Disorders
Alcoholism
Rats
Alcoholics
Ethanol
Animal Models
Alcohols
Carbohydrates
Animals
Fluoxetine
Curbs
Genetic Predisposition to Disease
Wistar Rats
Nutrition
Serotonin
Body Weight
Mood
Rat
Brain

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Alcoholism : Is it a model for the study of disorders of mood and consummatory behavior? / Li, T. K.; Lumeng, L.; McBride, W. J.; Murphy, J. M.

In: Annals of the New York Academy of Sciences, Vol. 499, 1987, p. 239-249.

Research output: Contribution to journalArticle

Li, T. K. ; Lumeng, L. ; McBride, W. J. ; Murphy, J. M. / Alcoholism : Is it a model for the study of disorders of mood and consummatory behavior?. In: Annals of the New York Academy of Sciences. 1987 ; Vol. 499. pp. 239-249.
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