Allele frequencies of the preproenkephalin A (PENK) gene CA repeat in Asians, African-Americans, and Caucasians

Lack of evidence for different allele frequencies in alcoholics

Rebecca Chan, A. W. McBride, H. R. Thomasson, A. Ykenney, David Crabb

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Evidence from animal models and from recent reports on the efficacy of the opioid antagonist naltrexone in the treatment of alcoholism suggests that the endogenous opioid systems may play a role in alcohol seeking behavior. The gene encoding preproenkephalin A (PENK) is flanked at its 3' end by a polymorphic (CA)(n) repeat. We determined the allele frequencies for this locus in samples of Chinese and Atayal living in Taiwan, Caucasians living in the United States and Byelorussia, and African-Americans living in the United States. We compared the allele frequencies of nonalcoholics in each population with those of alcoholics with or without alcohol-induced organ pathology. There was no difference in allele frequencies within any racial group when alcoholics with or without organ pathology were compared; there was also no difference in allele frequency between nonalcoholics and alcoholics within the two Asian populations, Caucasians, or African- Americans. There were highly significant differences in the frequency of the various length polymorphisms between the Asian, Caucasian, and African- American samples.

Original languageEnglish
Pages (from-to)533-535
Number of pages3
JournalAlcoholism: Clinical and Experimental Research
Volume18
Issue number3
DOIs
StatePublished - 1994

Fingerprint

Asian Americans
Pathology
Alcoholics
Gene Frequency
African Americans
Genes
Alcohols
Naltrexone
Gene encoding
Narcotic Antagonists
Polymorphism
Opioid Analgesics
Animals
Taiwan
Population
Alcoholism
Animal Models
preproenkephalin
Therapeutics

Keywords

  • Endorphin
  • Enkephalin
  • Gene
  • Population

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

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title = "Allele frequencies of the preproenkephalin A (PENK) gene CA repeat in Asians, African-Americans, and Caucasians: Lack of evidence for different allele frequencies in alcoholics",
abstract = "Evidence from animal models and from recent reports on the efficacy of the opioid antagonist naltrexone in the treatment of alcoholism suggests that the endogenous opioid systems may play a role in alcohol seeking behavior. The gene encoding preproenkephalin A (PENK) is flanked at its 3' end by a polymorphic (CA)(n) repeat. We determined the allele frequencies for this locus in samples of Chinese and Atayal living in Taiwan, Caucasians living in the United States and Byelorussia, and African-Americans living in the United States. We compared the allele frequencies of nonalcoholics in each population with those of alcoholics with or without alcohol-induced organ pathology. There was no difference in allele frequencies within any racial group when alcoholics with or without organ pathology were compared; there was also no difference in allele frequency between nonalcoholics and alcoholics within the two Asian populations, Caucasians, or African- Americans. There were highly significant differences in the frequency of the various length polymorphisms between the Asian, Caucasian, and African- American samples.",
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author = "Rebecca Chan and McBride, {A. W.} and Thomasson, {H. R.} and A. Ykenney and David Crabb",
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T2 - Lack of evidence for different allele frequencies in alcoholics

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AU - McBride, A. W.

AU - Thomasson, H. R.

AU - Ykenney, A.

AU - Crabb, David

PY - 1994

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N2 - Evidence from animal models and from recent reports on the efficacy of the opioid antagonist naltrexone in the treatment of alcoholism suggests that the endogenous opioid systems may play a role in alcohol seeking behavior. The gene encoding preproenkephalin A (PENK) is flanked at its 3' end by a polymorphic (CA)(n) repeat. We determined the allele frequencies for this locus in samples of Chinese and Atayal living in Taiwan, Caucasians living in the United States and Byelorussia, and African-Americans living in the United States. We compared the allele frequencies of nonalcoholics in each population with those of alcoholics with or without alcohol-induced organ pathology. There was no difference in allele frequencies within any racial group when alcoholics with or without organ pathology were compared; there was also no difference in allele frequency between nonalcoholics and alcoholics within the two Asian populations, Caucasians, or African- Americans. There were highly significant differences in the frequency of the various length polymorphisms between the Asian, Caucasian, and African- American samples.

AB - Evidence from animal models and from recent reports on the efficacy of the opioid antagonist naltrexone in the treatment of alcoholism suggests that the endogenous opioid systems may play a role in alcohol seeking behavior. The gene encoding preproenkephalin A (PENK) is flanked at its 3' end by a polymorphic (CA)(n) repeat. We determined the allele frequencies for this locus in samples of Chinese and Atayal living in Taiwan, Caucasians living in the United States and Byelorussia, and African-Americans living in the United States. We compared the allele frequencies of nonalcoholics in each population with those of alcoholics with or without alcohol-induced organ pathology. There was no difference in allele frequencies within any racial group when alcoholics with or without organ pathology were compared; there was also no difference in allele frequency between nonalcoholics and alcoholics within the two Asian populations, Caucasians, or African- Americans. There were highly significant differences in the frequency of the various length polymorphisms between the Asian, Caucasian, and African- American samples.

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