Allelic deletion at chromosome 9p21(p16) and 17p13(p53) in microdissected sporadic dysplastic nevus

Won Sang Park, Alexander Vortmeyer, Svetlana Pack, Paul H. Duray, Roland Böni, Amir Ali Guerami, Michael R. Emmert-Buck, Lance A. Liotta, Zhengping Zhuang

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

A critical area of chromosomal loss at region p16(9p21-22) and p53(17p13) has been implicated in the genesis of malignant melanoma. It is still unclear whether the genetic alterations can be detected in dysplastic nevus, a premalignant lesion of malignant melanoma. We have searched the frequency of p16 and p53 deletion in nine dysplastic nevi and 13 benign intradermal nevi with five microsatellite markers. Hemizygous deletion was detected in seven of nine (78%) dysplastic nevi at one or more loci for p16 and three of seven (43%) for p53, respectively. No loss of heterozygosity (LOH) was detected in any of the benign intradermal nevi. All three dysplastic nevi with LOH for p53 also showed LOH at p16. However, not all dysplastic nevi showing p16 deletion showed p53 gene deletion. Therefore, these data suggest that deletion of p16 may play an important role in the development of dysplastic nevus as an early event and that the changes may represent an early event in the development of malignant melanoma.

Original languageEnglish (US)
Pages (from-to)127-130
Number of pages4
JournalHuman Pathology
Volume29
Issue number2
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

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Dysplastic Nevus Syndrome
Chromosome Deletion
Loss of Heterozygosity
Intradermal Nevus
Melanoma
p53 Genes
Gene Deletion
Microsatellite Repeats

Keywords

  • Chromosome 17
  • Chromosome 9
  • Dysplastic nevus
  • Loss of heterozygosity
  • PCR

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Allelic deletion at chromosome 9p21(p16) and 17p13(p53) in microdissected sporadic dysplastic nevus. / Park, Won Sang; Vortmeyer, Alexander; Pack, Svetlana; Duray, Paul H.; Böni, Roland; Guerami, Amir Ali; Emmert-Buck, Michael R.; Liotta, Lance A.; Zhuang, Zhengping.

In: Human Pathology, Vol. 29, No. 2, 01.01.1998, p. 127-130.

Research output: Contribution to journalArticle

Park, WS, Vortmeyer, A, Pack, S, Duray, PH, Böni, R, Guerami, AA, Emmert-Buck, MR, Liotta, LA & Zhuang, Z 1998, 'Allelic deletion at chromosome 9p21(p16) and 17p13(p53) in microdissected sporadic dysplastic nevus', Human Pathology, vol. 29, no. 2, pp. 127-130. https://doi.org/10.1016/S0046-8177(98)90221-0
Park, Won Sang ; Vortmeyer, Alexander ; Pack, Svetlana ; Duray, Paul H. ; Böni, Roland ; Guerami, Amir Ali ; Emmert-Buck, Michael R. ; Liotta, Lance A. ; Zhuang, Zhengping. / Allelic deletion at chromosome 9p21(p16) and 17p13(p53) in microdissected sporadic dysplastic nevus. In: Human Pathology. 1998 ; Vol. 29, No. 2. pp. 127-130.
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