Allelic distribution of CTG18.1 in Caucasian populations: Association studies in bipolar disorder, schizophrenia, and ataxia

M. G. McInnis, T. Swift-Scanlanl, A. T. Mahoney, J. Vincent, G. Verheyen, T. Hung Lan, L. Oruc, O. Riess, C. Van Broeckhoven, H. Chen, J. L. Kennedy, D. F. MacKinnon, R. L. Margolis, S. G. Simpson, F. J. McMahon, E. Gershon, J. Nürnberger, T. Reich, J. R. Depaulo, C. A. Ross

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

CTG18.1 is a highly polymorphic and unstable CTG repeat within an intron of the SEF2-1 gene. We tested the CTG18.1 repeat length in affective disorder, schizophrenia, and nonspecific ataxia; these diseases all have shown clinical evidence for anticipation. There was no difference in the allele frequencies comparing the controls and disease groups. The most common allele contains 11 CAGs (35%) followed by alleles with 14-17 CAGs (35%). There was no difference in the distribution of the alleles in the cases vs controls for ataxia (P = 0.11), affective disorders (P = 0.21), or schizophrenia (P = 0.26). The frequency of unstable CTG18.1 alleles was approximately 3% in a population of N. European descent and is not related to the phenotypes tested.

Original languageEnglish (US)
Pages (from-to)439-442
Number of pages4
JournalMolecular Psychiatry
Volume5
Issue number4
DOIs
StatePublished - Jan 1 2000

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Keywords

  • Ataxia
  • Bipolar disorder
  • Schizophrenia
  • Triplet repeats

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

McInnis, M. G., Swift-Scanlanl, T., Mahoney, A. T., Vincent, J., Verheyen, G., Hung Lan, T., Oruc, L., Riess, O., Van Broeckhoven, C., Chen, H., Kennedy, J. L., MacKinnon, D. F., Margolis, R. L., Simpson, S. G., McMahon, F. J., Gershon, E., Nürnberger, J., Reich, T., Depaulo, J. R., & Ross, C. A. (2000). Allelic distribution of CTG18.1 in Caucasian populations: Association studies in bipolar disorder, schizophrenia, and ataxia. Molecular Psychiatry, 5(4), 439-442. https://doi.org/10.1038/sj.mp.4000747