Allelic Loss of the Active X Chromosome during Bladder Carcinogenesis

Liang Cheng, Gregory T. MacLennan, Chong Xian Pan, Timothy D. Jones, Curtiss R. Moore, Shaobo Zhang, Jian Gu, Namrata B. Patel, Chinghai Kao, Thomas A. Gardner

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Context.-Previous studies have shown that loss of the X chromosome is involved in the carcinogenesis of certain human malignancies. Objective.-To determine whether X-linked allelic losses occur during bladder tumorigenesis and whether such losses involve the active or the inactive X chromosome. Design.-We analyzed the deletion status of the X-linked human androgen receptor gene locus in 6 female patients who underwent radical cystectomies for muscle-invasive urothelial carcinoma of the urinary bladder. Four patients had coexisting urothelial carcinoma in situ. Analysis for inactivation of the X chromosome was carried out in parallel. Results.-Three cases were informative. Invasive tumor samples showed loss of heterozygosity involving the active allele at the androgen receptor locus in all 3 positive cases, whereas carcinoma in situ showed nonrandom X chromosome inactivation but not allelic deletion. Conclusions.-Our data suggest that allelic loss of the activated X chromosome is involved in bladder carcinogenesis and cancer progression.

Original languageEnglish (US)
Pages (from-to)187-190
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume128
Issue number2
StatePublished - Feb 1 2004

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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    Cheng, L., MacLennan, G. T., Pan, C. X., Jones, T. D., Moore, C. R., Zhang, S., Gu, J., Patel, N. B., Kao, C., & Gardner, T. A. (2004). Allelic Loss of the Active X Chromosome during Bladder Carcinogenesis. Archives of Pathology and Laboratory Medicine, 128(2), 187-190.