Allogeneic responses of human umbilical cord blood

G. Risdon, J. Gaddy, H. E. Broxmeyer

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Human umbilical cord blood (CB) is increasingly used as an alternative to bone marrow as a source of stem and progenitor cells for pediatric patients. We have evaluated the alloreactive potential of cord blood T cells in vitro. Our findings demonstrate that in a primary mixed leukocyte culture CB T cells demonstrate strong proliferative responses to allogeneic stimulation but little to no generation of cytotoxic effector function. Furthermore, restimulation of primary cultures results in a state of proliferative unresponsiveness. Such diminished cytotoxic and proliferative responses may, in part, be related to the low incidence of graft vs. host disease thus far noted in human CB transplants.

Original languageEnglish (US)
Pages (from-to)566-572
Number of pages7
JournalBlood Cells
Volume20
Issue number2-3
StatePublished - Dec 1 1994

Keywords

  • allogeneic response
  • graft vs. host disease
  • human umbilical cord blood
  • mononuclear cells

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Allogeneic responses of human umbilical cord blood'. Together they form a unique fingerprint.

Cite this