Alpha-2 adrenergic challenge with guanfacine one month after mild traumatic brain injury

Altered working memory and BOLD response

Thomas W. McAllister, Brenna McDonald, Laura A. Flashman, Richard B. Ferrell, Tor D. Tosteson, Norman N. Yanofsky, Margaret R. Grove, Andrew Saykin

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Alterations in working memory (WM) are common after traumatic brain injury (TBI). Frontal catecholaminergic systems, including the alpha-2 adrenergic system, modulate WM function and may be affected in TBI. We hypothesized that administration of an alpha-2 adrenergic agonist might improve WM after mild TBI (MTBI). Thirteen individuals with MTBI 1. month after injury and 14 healthy controls (HC) were challenged with guanfacine and placebo prior to administration of a verbal WM functional MRI task. Guanfacine was associated with improved WM performance in the MTBI but not the HC group. On guanfacine the MTBI group showed increased activation within a WM task-specific region of interest. Findings are consistent with the hypothesis that alterations in WM after MTBI may be improved with the alpha-2 agonist guanfacine.

Original languageEnglish
Pages (from-to)107-114
Number of pages8
JournalInternational Journal of Psychophysiology
Volume82
Issue number1
DOIs
StatePublished - Oct 2011

Fingerprint

Guanfacine
Brain Concussion
Short-Term Memory
Adrenergic Agents
Adrenergic alpha-2 Receptor Agonists
Placebos
Magnetic Resonance Imaging
Control Groups
Wounds and Injuries

Keywords

  • Alpha-2 adrenergic agonist
  • Functional MRI
  • Guanfacine
  • Traumatic brain injury
  • Working memory

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)
  • Neuropsychology and Physiological Psychology

Cite this

Alpha-2 adrenergic challenge with guanfacine one month after mild traumatic brain injury : Altered working memory and BOLD response. / McAllister, Thomas W.; McDonald, Brenna; Flashman, Laura A.; Ferrell, Richard B.; Tosteson, Tor D.; Yanofsky, Norman N.; Grove, Margaret R.; Saykin, Andrew.

In: International Journal of Psychophysiology, Vol. 82, No. 1, 10.2011, p. 107-114.

Research output: Contribution to journalArticle

McAllister, Thomas W. ; McDonald, Brenna ; Flashman, Laura A. ; Ferrell, Richard B. ; Tosteson, Tor D. ; Yanofsky, Norman N. ; Grove, Margaret R. ; Saykin, Andrew. / Alpha-2 adrenergic challenge with guanfacine one month after mild traumatic brain injury : Altered working memory and BOLD response. In: International Journal of Psychophysiology. 2011 ; Vol. 82, No. 1. pp. 107-114.
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