Alpha2-adrenergic receptor function in patients with unipolar and bipolar affective disorders

Marian S. Kafka, John Nurnberger, Larry Siever, Steven Targum, Thomas W. Uhde, Elliot S. Gershon

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Alpha2-adrenergic receptor function was measured in platelets from unipolar (UP) depressed, bipolar (BP) depressed, and bipolar euthymic patients and normal control subjects. Only the platelets from UP depressed patients were different from control in having an increased number of α2-receptors, a decreased percent norepinephrine inhibition of prostaglandin E1 (PGE1)-stimulated cyclic AMP (cAMP) production, and a decrease in PGE1 stimulation of cAMP production. Platelets from BP patients, depressed or euthymic, were not significantly different from control subjects. These preliminary data suggest that α2-adrenergic receptor function and PGE1 stimulation of cAMP production are diminished in UP patients.

Original languageEnglish (US)
Pages (from-to)163-169
Number of pages7
JournalJournal of Affective Disorders
Volume10
Issue number2
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Mood Disorders
Bipolar Disorder
Adrenergic Receptors
Alprostadil
Cyclic AMP
Blood Platelets
Norepinephrine

Keywords

  • Affective disorders
  • Alpha-adrenergic receptor
  • Cyclic AMP
  • Platelet

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Alpha2-adrenergic receptor function in patients with unipolar and bipolar affective disorders. / Kafka, Marian S.; Nurnberger, John; Siever, Larry; Targum, Steven; Uhde, Thomas W.; Gershon, Elliot S.

In: Journal of Affective Disorders, Vol. 10, No. 2, 1986, p. 163-169.

Research output: Contribution to journalArticle

Kafka, Marian S. ; Nurnberger, John ; Siever, Larry ; Targum, Steven ; Uhde, Thomas W. ; Gershon, Elliot S. / Alpha2-adrenergic receptor function in patients with unipolar and bipolar affective disorders. In: Journal of Affective Disorders. 1986 ; Vol. 10, No. 2. pp. 163-169.
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